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Chilli peppers hold promise of preventing liver damage and progression

Date:
April 23, 2015
Source:
European Association for the Study of the Liver
Summary:
New research shows that the daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage.
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Results revealed today at the International Liver Congress™ 2015 show that the daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage.

In the study, capsaicin was found to reduce the activation of hepatic stellate cells (HSCs) in mice models. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.

The mice were split into two groups and received capsaicin in their food:

  • After three days of bile duct ligation (BDL) in which the common bile duct is obstructed, leading to bile accumulation and liver fibrosis
  • Before and during chronic carbon tetrachloride treatment (CCl4). CCl4 is an inorganic compound that was widely used in fire extinguishers, as a precursor to refrigerants and as a cleaning agent. It is now known to be one of the most potent hepatotoxins

The study demonstrates that capsaicin partially improved liver damage in the BDL mice and inhibited further progression of the injury. In the second group of CCl4-treated mice, capsaicin prevented livers from injury development but did not reduce the fibrosis when it was already established.

These results support the need for further investigation into capsaicin for the treatment and prevention of liver injury and fibrosis.


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Materials provided by European Association for the Study of the Liver. Note: Content may be edited for style and length.


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European Association for the Study of the Liver. "Chilli peppers hold promise of preventing liver damage and progression." ScienceDaily. ScienceDaily, 23 April 2015. <www.sciencedaily.com/releases/2015/04/150423085442.htm>.
European Association for the Study of the Liver. (2015, April 23). Chilli peppers hold promise of preventing liver damage and progression. ScienceDaily. Retrieved March 26, 2017 from www.sciencedaily.com/releases/2015/04/150423085442.htm
European Association for the Study of the Liver. "Chilli peppers hold promise of preventing liver damage and progression." ScienceDaily. www.sciencedaily.com/releases/2015/04/150423085442.htm (accessed March 26, 2017).