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Profiling approach to enable right lung cancer treatment match

Date:
May 5, 2015
Source:
Manchester University
Summary:
A new way to genetically profile lung cancer samples has been developed by researchers, potentially allowing doctors to more easily identify the most appropriate treatment for patients.
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Manchester researchers have tested a new way to genetically profile lung cancer samples, potentially allowing doctors to more easily identify the most appropriate treatment for patients.

Non-small cell lung cancer (NSCLC) represents over 85% of lung cancer cases. The recent introduction of targeted therapies has led to improved patient survival, but only patients whose tumors have a specific genetic change are eligible for such treatments.

Identifying individual patients who may benefit from targeted therapy is becoming an essential part of treatment planning, but many current genetic analysis methods such as next generation sequencing require relatively large amounts of tumor material.

Dr Fiona Blackhall, a senior lecturer in The University of Manchester's Institute of Cancer Sciences and a consultant based at The Christie NHS Foundation Trust -- both part of the Manchester Cancer Research Centre -- said: "Unfortunately the biopsy samples we take from these patients are generally quite small. In this study we looked at an alternative genetic screen that utilises a much smaller tissue biopsy to see if it can detect a range of changes in 26 key genes."

The Lung Cancer research group working with the Manchester Centre for Genomic Medicine used the LungCarta platform to screen tumor samples from 90 NSCLC patients. They found that they could analyse over 95% of the samples and they detected genetic changes (mutations) that could be used for selection of treatment in around half of the biopsy samples.

"This type of genetic testing appears to be a clinically useful diagnostic screening test that can be used on small biopsy samples. This should allow us to better match lung cancer patients to the right treatment and we have now started to use this method of testing to identify suitable clinical trials for our patients," added Dr Blackhall.


Story Source:

Materials provided by Manchester University. Note: Content may be edited for style and length.


Journal Reference:

  1. Anne Marie Quinn, Nicholas Hickson, Megan Adaway, Lynsey Priest, Erich Jaeger, Nitin Udar, Catherine Keeling, Martyna Kamieniorz, Caroline Dive, Andrew Wallace, Richard J. Byers, William G. Newman, Daisuke Nonaka, Fiona H. Blackhall. Diagnostic Mutation Profiling and Validation of Non–Small-Cell Lung Cancer Small Biopsy Samples using a High Throughput Platform. Journal of Thoracic Oncology, 2015; 10 (5): 784 DOI: 10.1097/JTO.0000000000000473

Cite This Page:

Manchester University. "Profiling approach to enable right lung cancer treatment match." ScienceDaily. ScienceDaily, 5 May 2015. <www.sciencedaily.com/releases/2015/05/150505082942.htm>.
Manchester University. (2015, May 5). Profiling approach to enable right lung cancer treatment match. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/05/150505082942.htm
Manchester University. "Profiling approach to enable right lung cancer treatment match." ScienceDaily. www.sciencedaily.com/releases/2015/05/150505082942.htm (accessed May 23, 2017).

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