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Cause of heart damage in sepsis patients identified

Date:
July 9, 2015
Source:
University of Liverpool
Summary:
Sepsis is the most common cause of death in hospitalized critically ill people and affects up to 18 million people world-wide annually. A common cause of heart damage in patients with sepsis has now been identified by researchers.
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Researchers at the University of Liverpool's Institute of Infection and Global Health (IGH) have discovered a common cause of heart damage in patients with sepsis.

Sepsis is the most common cause of death in hospitalized critically ill people and affects up to 18 million people world-wide annually.

The electrical and mechanical malfunctions of the heart have been poorly understood in sepsis, with underdeveloped clinical management strategies, as a consequence. This new discovery, however, promises to benefit a high number of patients with heart failure or rhythm abnormalities that complicate sepsis.

The team discovered that nuclear proteins, called histones, induce damage to heart muscle cells when released into the blood circulation following extensive cell damage in sepsis.

Blood levels of histones, however, are robust biomarkers that can predict which patients are more likely to develop heart complications.

Dr Yasir Alhamdi, from the University's Institute of Infection and Global Health, said: "This new discovery has important clinical implications. Firstly, we now provide a much-needed explanation for why cardiac injury markers are high in sepsis.

"Secondly, histone levels in the blood can potentially be used at an early stage to predict which septic patients are at highest risk of developing deadly heart complications. This can improve overall management of patients with sepsis worldwide."

The research team has also developed and tested specific antibodies that can directly neutralise the toxic effects of histones in the blood circulation and found that their use can significantly prevent the development of heart complications in sepsis.

Professor Cheng-Hock Toh, from the University's Institute of Infection and Global Health, said: "The translational impact to patients with sepsis can extend beyond biomarker prediction of heart complications, to novel targeted treatment for improved survival.

"This discovery could therefore enable us to better stratify patients for more precise and personalised treatment in sepsis."

The study was funded by the British Heart Foundation (BHF) and the National Institute of Health Research (NIHR). The paper, 'Circulating histones are major mediators of cardiac injury in patients with sepsis,' is published in the journal Critical Care Medicine.


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Materials provided by University of Liverpool. Note: Content may be edited for style and length.


Journal Reference:

  1. Yasir Alhamdi, Simon T. Abrams, Zhenxing Cheng, Shengjie Jing, Dunhao Su, Zhiyong Liu, Steven Lane, Ingeborg Welters, Guozheng Wang, Cheng-Hock Toh. Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis. Critical Care Medicine, 2015; 1 DOI: 10.1097/CCM.0000000000001162

Cite This Page:

University of Liverpool. "Cause of heart damage in sepsis patients identified." ScienceDaily. ScienceDaily, 9 July 2015. <www.sciencedaily.com/releases/2015/07/150709103050.htm>.
University of Liverpool. (2015, July 9). Cause of heart damage in sepsis patients identified. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150709103050.htm
University of Liverpool. "Cause of heart damage in sepsis patients identified." ScienceDaily. www.sciencedaily.com/releases/2015/07/150709103050.htm (accessed May 23, 2017).

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