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Researchers describe the role of water in protein folding

Date:
September 21, 2015
Source:
Universidad de Barcelona
Summary:
A new study describes the contribution of water to the three-dimensional structure of proteins that allows them performing their biological function.
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The study describes the contribution of water to the three-dimensional structure of proteins that allows them performing their biological function.
Credit: Image courtesy of Universidad de Barcelona

A study developed by researchers at the Faculty of Physics of the University of Barcelona (UB), published in the journal Physical Review Letters, describes the contribution of water to the three-dimensional structure of proteins that allows them performing their biological function.

Giancarlo Franzese, professor in the Department of Fundamental Physics of the UB and leader of the study, explains that "so far, data came from experiments and theories based on hypotheses that are hard to prove and simulations that work only under conditions of high pressure and temperature, but they failed under conditions of low pressure and temperature."

Knowledge about how water works at the protein interface has enabled the research team to prove that "increased stability of hydrogen bonds at molecular hydrophobic interfaces and increased compressibility at these interfaces allow understanding how water contributes to protein folding in a wide range of pressures and temperatures," explains Valentino Bianco that developed this work as part of his doctoral thesis.

It is important to highlight that protein folding is not only due to water activity as protein waste interactions and the presence of cavities also play an important role in the process. The importance of the study relies on the fact that, by using Monte Carlo simulations, it proves that the water unique properties are key to understand protein folding mechanisms and biological function. "The study highlights that water is essential for life, and it can be useful to develop advanced computational tools for protein engineering that can be used in medicine," concluded Franzese.


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Materials provided by Universidad de Barcelona. Note: Content may be edited for style and length.


Journal Reference:

  1. Valentino Bianco, Giancarlo Franzese. Contribution of Water to Pressure and Cold Denaturation of Proteins. Physical Review Letters, 2015; 115 (10) DOI: 10.1103/PhysRevLett.115.108101

Cite This Page:

Universidad de Barcelona. "Researchers describe the role of water in protein folding." ScienceDaily. ScienceDaily, 21 September 2015. <www.sciencedaily.com/releases/2015/09/150921091305.htm>.
Universidad de Barcelona. (2015, September 21). Researchers describe the role of water in protein folding. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/09/150921091305.htm
Universidad de Barcelona. "Researchers describe the role of water in protein folding." ScienceDaily. www.sciencedaily.com/releases/2015/09/150921091305.htm (accessed May 23, 2017).

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