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Protein successfully targets Alzheimer's in mice

Date:
October 20, 2015
Source:
KTH The Royal Institute of Technology
Summary:
A newly-developed protein has successfully prevented dementia from occurring in lab mice carrying human Alzheimer's genes, raising the possibility for development of new treatments for the disease.
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Representative brain sections, immunostained with ?-A? antibodies 6E10/4G8. Hippocampus of a) negative control-treated and b) ZSY M73-ABD treated mice. Cortex of d) control-treated and e) ZSY M73-treated mice.
Credit: Image courtesy of KTH The Royal Institute of Technology

A newly-developed protein has successfully prevented dementia from occurring in lab mice carrying human Alzheimer's genes, raising the possibility for development of new treatments for the disease.

Hanna Lindberg, a researcher at Stockholm's KTH Royal Institute of Technology, worked with colleagues in Sweden and New York to develop a so-called binding protein that could target amyloid beta peptides, which are associated with Alzheimer's disease.

Lindberg says that the test results could provide the basis for work on new treatments for Alzheimer's.

When equipped with the binding protein, the researchers found that laboratory mice carrying the genes for human Alzheimer's did not develop disease-related memory impairment or impaired cognitive ability, Lindberg says.

The proteins also prevented the occurrence of amyloid plaques on the brains of lab mice. These plaques result from the large-scale production of amyloid beta peptides in the brains of Alzheimer's patients.

"We greatly reduced the amounts of amyloid beta peptides in the brains of these mice," Lindberg says.

Binding proteins get their name from their ability to act as an agent in binding molecules together. These proteins mimic the function of antibodies but are much smaller. The proteins used by Lindberg and her team are based on affibodies -- an engineered class of proteins that can be designed to bind tightly and specifically against various diseases' proteins.

"In our case, we have created lots of variations of the same binding protein to find the optimal version for the target peptides which are associated with Alzheimer's," Lindberg says.

So far, she says, the results are promising. "The mice that received the treatment with affibody molecules behave just like healthy animals when it comes to memory and cognitive ability," she says.

Lindberg says a drug could become available within a decade if all the conditions are favorable.

"Alzheimer's is the most common dementia disease today," she says. "There are medicines for the symptoms, but no effective treatment method. The medications do not attack the fundamental disease mechanisms, and they tend to become inactive after a while."

According to the Alzheimer's Association, 35 million people suffer from Alzheimer's disease today, and this figure will triple by the year 2050. It usually develops slowly and gradually gets worse as brain function declines and brain cells eventually wither and die. Ultimately, Alzheimer's is fatal, and currently, there is no cure.

The research project was conducted in collaboration with Professor Thomas Wisniewski at New York University School of Medicine and Professor Torleif Härd at the Swedish University of Agricultural (SLU).


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Materials provided by KTH The Royal Institute of Technology. Note: Content may be edited for style and length.


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KTH The Royal Institute of Technology. "Protein successfully targets Alzheimer's in mice." ScienceDaily. ScienceDaily, 20 October 2015. <www.sciencedaily.com/releases/2015/10/151020145511.htm>.
KTH The Royal Institute of Technology. (2015, October 20). Protein successfully targets Alzheimer's in mice. ScienceDaily. Retrieved February 19, 2017 from www.sciencedaily.com/releases/2015/10/151020145511.htm
KTH The Royal Institute of Technology. "Protein successfully targets Alzheimer's in mice." ScienceDaily. www.sciencedaily.com/releases/2015/10/151020145511.htm (accessed February 19, 2017).