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Aug. 13, 2021 The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this ...
Nov. 10, 2022 Researchers have discovered factors that may make breast and ovarian cancers associated with BRCA1/2 gene mutations more likely to ...
June 21, 2023 Researchers have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against ...
Jan. 25, 2022 Faulty versions of the BRCA1 and BRCA2 genes are well known to increase the risk of breast cancer in men and women, and in ovarian cancer. Now BRCA1 and BRCA2 have been linked to several other ...
Aug. 12, 2021 PARP inhibitors, used to treat patients with cancer of the breast, ovaries, prostate and pancreas, work by inducing persistent DNA gaps in tumor cells with BRCA1 and BRCA2 mutations. The discovery ...
Jan. 20, 2022 Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and machine learning ...
Jan. 17, 2024 Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing ...
Nov. 15, 2022 Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study. The discovery has potential implications ...
Apr. 5, 2021 Scientists has illuminated the functions of mysterious structures in cells called 'nuclear speckles,' showing that they can work in partnership with a key protein to enhance the activities ...
Sep. 16, 2021 In a surprising new finding in mice, researchers have discovered that many genes linked to human cancer block the body's natural defense against ...