Science News
from research organizations

COPD may cause structural changes within the brain

Patients with COPD demonstrate decrease in areas of the brain that process breathlessness, fear, and sensitivity to pain

Date:
February 9, 2016
Source:
American College of Chest Physicians
Summary:
Patients with COPD demonstrated gray matter decreases in areas of the brain that process breathlessness, fear and sensitivity to pain. The study found patients with COPD show regionally decreased gray matter volume in the anterior, mid, and posterior cingulate cortex, hippocampus, and amygdala. Levels of degeneration in certain areas of the brain were also impacted by longer disease duration. Those individuals showed a greater fear of breathlessness and fear of physical activity, which can affect the course of the disease.
Share:
FULL STORY

Chronic Obstructive Pulmonary Disease (COPD), a condition impacting nearly 24 million Americans, is often associated with disease-specific fears and avoidance of physical activity. Little is known of the structural brain processes that occur in COPD patients. A study published in the February issue of the journal CHEST found that patients with COPD demonstrated gray matter decreases in areas of the brain that process breathlessness, fear and sensitivity to pain.

The study found patients with COPD show regionally decreased gray matter volume in the anterior, mid, and posterior cingulate cortex, hippocampus, and amygdala. Levels of degeneration in certain areas of the brain were also impacted by longer disease duration. Those individuals showed a greater fear of breathlessness and fear of physical activity, which can affect the course of the disease.

Researchers tested 30 stable outpatients with moderate-to-severe COPD and 30 control subjects with no history of the disease. All study participants underwent an MRI compatibility check to obtain structural brain images. Patients were also tested for lung function using spirometry, and assessed with the COPD Anxiety Questionnaire (CAF).

"Targeting disease-specific fears in patients with COPD might not only improve outcomes of clinical interventions such as pulmonary rehabilitation, but also reverse structural brain changes in these patients," said Andreas von Leupoldt, PhD from the Research Group Health Psychology, University of Leuven in Belgium.

The complete study, Brain Changes in Patients with Chronic Obstructive Pulmonary Disease, can be viewed in February issue of the journal CHEST.


Story Source:

Materials provided by American College of Chest Physicians. Note: Content may be edited for style and length.


Journal Reference:

  1. Roland W. Esser, M. Cornelia Stoeckel, Anne Kirsten, Henrik Watz, Karin Taube, Kirsten Lehmann, Sibylle Petersen, Helgo Magnussen, Andreas von Leupoldt. Structural Brain Changes in Patients With COPD. Chest, 2016; 149 (2): 426 DOI: 10.1378/chest.15-0027

Cite This Page:

American College of Chest Physicians. "COPD may cause structural changes within the brain: Patients with COPD demonstrate decrease in areas of the brain that process breathlessness, fear, and sensitivity to pain." ScienceDaily. ScienceDaily, 9 February 2016. <www.sciencedaily.com/releases/2016/02/160209121733.htm>.
American College of Chest Physicians. (2016, February 9). COPD may cause structural changes within the brain: Patients with COPD demonstrate decrease in areas of the brain that process breathlessness, fear, and sensitivity to pain. ScienceDaily. Retrieved September 26, 2016 from www.sciencedaily.com/releases/2016/02/160209121733.htm
American College of Chest Physicians. "COPD may cause structural changes within the brain: Patients with COPD demonstrate decrease in areas of the brain that process breathlessness, fear, and sensitivity to pain." ScienceDaily. www.sciencedaily.com/releases/2016/02/160209121733.htm (accessed September 26, 2016).