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Blood flow measurements in microfluidic devices fabricated by a micromilling technique

Date:
April 13, 2016
Source:
Bentham Science Publishers
Summary:
Researchers have shown the ability of a micromilling machine to manufacture microchannels, and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma.
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In this work, Dr. Diana and fellow researchers propose a low cost technique able to produce microfluidic devices for biomedical applications. The most common technique to fabricate biomedical microdevices is soft-lithography. However, it is a costly and time-consuming technique. Progress in manufacturing milling tools smaller than 100 µm, has enabled the use of micromilling machines to fabricate microfluidic devices capable of performing cell separation.

The researchers show not only the ability of a micromilling machine to fabricate microchannels down to 30 µm but also the ability of the manufactured microfluidic device to perform partial separation of red blood cells from plasma. They have performed blood flow visualization and measurements of the cell-free layer thickness by using a high-speed video microscopy system and demonstrated the advantages and limitations of the described micromilling fabrication technique to produce microfluidic devices for cellular-scale flow studies.


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Materials provided by Bentham Science Publishers. Note: Content may be edited for style and length.


Journal Reference:

  1. Jaron Singhal, Diana Pinho, Raquel Lopes, Patricia C. Sousa, Valdemar Garcia, Helmut Schütte, Rui Lima and Stefan Gassmann. Blood Flow Visualization and Measurements in Microfluidic Devices Fabricated by a Micromilling Technique. Micro and Nanosystems, 7(3): 148-153

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Bentham Science Publishers. "Blood flow measurements in microfluidic devices fabricated by a micromilling technique." ScienceDaily. ScienceDaily, 13 April 2016. <www.sciencedaily.com/releases/2016/04/160413180329.htm>.
Bentham Science Publishers. (2016, April 13). Blood flow measurements in microfluidic devices fabricated by a micromilling technique. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/04/160413180329.htm
Bentham Science Publishers. "Blood flow measurements in microfluidic devices fabricated by a micromilling technique." ScienceDaily. www.sciencedaily.com/releases/2016/04/160413180329.htm (accessed May 23, 2017).

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