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Pregnant mothers may shield unborn young from damage, risk their own mortality

Date:
May 18, 2016
Source:
University of Exeter
Summary:
Mammals can protect their unborn young from harmful chemicals in their blood even at the expense of their own survival odds, a study into mongooses suggests.
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Mammals can protect their unborn young from harmful chemicals in their blood even at the expense of their own survival odds, a study into mongooses conducted by researchers at the University of Exeter suggests.

Chemicals causing oxidative stress are a normal metabolic by-product in all animals but can cause oxidative damage to tissues and cells, leading to aging. Current theory predicts that females should show higher levels of such oxidative damage when they are pregnant.

This five-year study into banded mongooses carried out by Dr Emma Vitikainen and colleagues at the Centre for Ecology and Conservation at the University of Exeter's Penryn Campus found the opposite pattern. Mothers with the lowest levels of oxidative damage when pregnant also had the greatest number of surviving offspring.

The research showed oxidative damage to be strongly linked to adult survival in both sexes. Unusually male banded mongooses live longer than females, and they also had lower levels of oxidative damage across their lives. While females reduced their amount of damage during pregnancy, the level of damage bounced back after breeding.

Dr Vitikainen, lead author of the study said: "We previously suggested that oxidative damage might be harmful for unborn offspring, as well as mothers themselves. Our current results support this hypothesis, and provide evidence that pregnant females dial down their level of damage to shield their unborn young from harm during sensitive developmental windows even if they bear a cost at other times."

Studies in humans have shown that oxidative damage can be an indicator for pathologies, such as complications during pregnancy, and even predict survival from types of cancer. The findings are the first to show that similar patterns exist also in wild animals and suggest oxidative damage can be a marker for fertility and survival across species.

The researchers studied a population of 251 animals over 5 years at Uganda's Queen Elizabeth National Park and used mathematical modelling to investigate how oxidative shielding of offspring can evolve. They measured levels of malondialdehyde, a marker of oxidative damage to lipids, in the circulation of mothers before, during and after they were pregnant. They then assessed whether levels explained variation in the number of offspring that survived to emerge from the underground den where they are born.

Dr Jon Blount, a senior researcher on the study, said: "These results suggest we may need to rethink current theory about why animals deteriorate with age, and how parents can influence the development of their offspring."


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Materials provided by University of Exeter. Note: Content may be edited for style and length.


Journal Reference:

  1. Emma I. K. Vitikainen, Michael A. Cant, Jennifer L. Sanderson, Christopher Mitchell, Hazel J. Nichols, Harry H. Marshall, Faye J. Thompson, Jason S. Gilchrist, Sarah J. Hodge, Rufus A. Johnstone, Jonathan D. Blount. Evidence of Oxidative Shielding of Offspring in a Wild Mammal. Frontiers in Ecology and Evolution, 2016; 4 DOI: 10.3389/fevo.2016.00058

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University of Exeter. "Pregnant mothers may shield unborn young from damage, risk their own mortality." ScienceDaily. ScienceDaily, 18 May 2016. <www.sciencedaily.com/releases/2016/05/160518220603.htm>.
University of Exeter. (2016, May 18). Pregnant mothers may shield unborn young from damage, risk their own mortality. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/05/160518220603.htm
University of Exeter. "Pregnant mothers may shield unborn young from damage, risk their own mortality." ScienceDaily. www.sciencedaily.com/releases/2016/05/160518220603.htm (accessed May 23, 2017).

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