Science News
from research organizations

Combo immunotherapy for advanced melanoma: Two therapies may be better than one

Small clinical trial finds checkpoint inhibitors could boost T-cell therapy for metastatic melanoma

Date:
June 6, 2016
Source:
Fred Hutchinson Cancer Research Center
Summary:
A new metastatic melanoma study suggests that a combination of two immunotherapies may be better than one. One treatment uses a patient's own T cells modified in the lab to more powerfully recognize and attack tumors; the other treatment, a 'checkpoint inhibitor,' releases the brakes on the body's natural immune system.
Share:
FULL STORY

A new metastatic melanoma study suggests that a combination of two immunotherapies may be better than one:

  • One treatment uses a patient's own T cells modified in the lab to more powerfully recognize and attack tumors;
  • The other treatment, a "checkpoint inhibitor," releases the brakes on the body's natural immune system.

Researchers at Fred Hutchinson Cancer Research Center in Seattle say the study, conducted between 2011 and 2013, "opens the door" to more studies of combination immunotherapy to fight metastatic melanoma and possibly other cancers.

The findings will appear in the Journal of Clinical Oncology.

Key Findings: 

Of 10 study participants:

  • three experienced disease progression
  • three had their disease stabilize
  • two had a partial response before the disease progressed and metastasized
  • two experienced complete remission
  • Five of the 10 were still alive three to five years after starting the treatment. In 2011, when the study began, patients with metastatic melanoma faced an average survival time that could be measured in months.
  • With only 10 patients in the trial, definitive conclusions cannot be reached. But one of the patients -- whose case study was recently published in the Journal of Experimental Medicine -- had previously received a checkpoint inhibitor and an earlier version of T-cell therapy. Neither treatment had worked independently, but the combination approach -- which included newer T-cell technology -- apparently drove the cancer into remission.

"This suggests that you can probably 'rescue' patients who do not respond to one form of treatment by doing combinations," says Dr. Aude Chapuis, first author, a medical oncologist and an adult hematopoietic stem cell transplant (HCT) physician with a strong background in immunology and adoptive T-cell transfer studies in humans.


Story Source:

Materials provided by Fred Hutchinson Cancer Research Center. Note: Content may be edited for style and length.


Journal Reference:

  1. A. G. Chapuis, I. M. Roberts, J. A. Thompson, K. A. Margolin, S. Bhatia, S. M. Lee, H. L. Sloan, I. P. Lai, E. A. Farrar, F. Wagener, K. C. Shibuya, J. Cao, J. D. Wolchok, P. D. Greenberg, C. Yee. T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression. Journal of Clinical Oncology, 2016; DOI: 10.1200/JCO.2015.65.5142

Cite This Page:

Fred Hutchinson Cancer Research Center. "Combo immunotherapy for advanced melanoma: Two therapies may be better than one: Small clinical trial finds checkpoint inhibitors could boost T-cell therapy for metastatic melanoma." ScienceDaily. ScienceDaily, 6 June 2016. <www.sciencedaily.com/releases/2016/06/160606200054.htm>.
Fred Hutchinson Cancer Research Center. (2016, June 6). Combo immunotherapy for advanced melanoma: Two therapies may be better than one: Small clinical trial finds checkpoint inhibitors could boost T-cell therapy for metastatic melanoma. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2016/06/160606200054.htm
Fred Hutchinson Cancer Research Center. "Combo immunotherapy for advanced melanoma: Two therapies may be better than one: Small clinical trial finds checkpoint inhibitors could boost T-cell therapy for metastatic melanoma." ScienceDaily. www.sciencedaily.com/releases/2016/06/160606200054.htm (accessed May 25, 2017).

RELATED STORIES