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Reforming clinical research to reduce waste

Date:
June 21, 2016
Source:
PLOS
Summary:
Many billions of dollars are spent on clinical research every year, yet much of the knowledge produced is not useful for guiding clinical decision making. Because many of the features that make clinical research reliable as a basis for clinical practice can be identified, more useful clinical research could easily be produced at the same or even at massively reduced cost, according to new research.
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Most clinical research is not useful to clinicians. This could change.

Many billions of dollars are spent on clinical research every year, yet much of the knowledge produced is not useful for guiding clinical decision making. Because many of the features that make clinical research reliable as a basis for clinical practice can be identified, more useful clinical research could easily be produced at the same or even at massively reduced cost, according to John Ioannidis from Stanford University, US, in an Essay published in PLOS Medicine.

Waste across medical research (clinical or other types) has been estimated as consuming 85% of the total cost. In his article Professor Ioannidis outlines the features that make clinical research useful, which include those relating to problem base, context placement, information gain, pragmatism, patient centeredness, value for money, feasibility, and transparency. He argues that reforming clinical research to take these features more directly into account would increase its usefulness to those providing care.

He concludes, "[o]verall, not only are most research findings false, but, furthermore, most of the true findings are not useful. Medical interventions should and can result in huge human benefit. It makes no sense to perform clinical research without ensuring clinical utility. Reform and improvement are overdue."


Story Source:

Materials provided by PLOS. Note: Content may be edited for style and length.


Journal Reference:

  1. John P. A. Ioannidis. Why Most Clinical Research Is Not Useful. PLOS Medicine, 2016; 13 (6): e1002049 DOI: 10.1371/journal.pmed.1002049

Cite This Page:

PLOS. "Reforming clinical research to reduce waste." ScienceDaily. ScienceDaily, 21 June 2016. <www.sciencedaily.com/releases/2016/06/160621154952.htm>.
PLOS. (2016, June 21). Reforming clinical research to reduce waste. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/06/160621154952.htm
PLOS. "Reforming clinical research to reduce waste." ScienceDaily. www.sciencedaily.com/releases/2016/06/160621154952.htm (accessed May 23, 2017).

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