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New lipid-lowering drugs help patients reduce LDL cholesterol

Date:
August 1, 2016
Source:
Wiley
Summary:
A recent analysis indicates that adding new therapies called anti-PCSK9 antibodies to other lipid-lowering treatments can help patients lower their LDL cholesterol levels.
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A recent analysis indicates that adding new therapies called anti-PCSK9 antibodies to other lipid-lowering treatments can help patients lower their LDL cholesterol levels.

Mutations in the gene that encodes PCSK9 (proprotein convertase subtilisin/kexin type 9) have been linked to high cholesterol. PCSK9 causes elevated blood levels of LDL cholesterol because it binds to the LDL receptor. Two anti-PCSK9 antibodies have recently been approved by the US Food and Drug Administration and the European Medicines Agency: alirocumab and evolocumab.

Researchers identified 12 studies of alirocumab and nine of evolocumab, including more than 10,000 patients, most of whom were taking statins but still had elevated cholesterol. All studies demonstrated a reduction in LDL cholesterol with the anti-PCSK9 antibodies. Up to 87% of patients receiving alirocumab and up to 98% receiving evolocumab reached LDL cholesterol goals.

"Both anti-PSCK9 antibodies have cardiovascular outcome studies ongoing with results expected in 2017. We are looking forward to them since it is rather unusual to have results of large outcome trials so soon after the launch of a drug in the market," said Prof. Ioanna Gouni-Berthold, lead author of the British Journal of Clinical Pharmacology study.


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Materials provided by Wiley. Note: Content may be edited for style and length.


Journal Reference:

  1. Ioanna Gouni-Berthold et al. Systematic review of published phase 3 data on anti-PCSK9 monoclonal antibodies in patients with hypercholesterolaemia. British Journal of Clinical Pharmacology, 2016 DOI: 10.1111/bcp.13066

Cite This Page:

Wiley. "New lipid-lowering drugs help patients reduce LDL cholesterol." ScienceDaily. ScienceDaily, 1 August 2016. <www.sciencedaily.com/releases/2016/08/160801131056.htm>.
Wiley. (2016, August 1). New lipid-lowering drugs help patients reduce LDL cholesterol. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/08/160801131056.htm
Wiley. "New lipid-lowering drugs help patients reduce LDL cholesterol." ScienceDaily. www.sciencedaily.com/releases/2016/08/160801131056.htm (accessed May 23, 2017).

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