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Targeting norovirus 'noxiousness'

Date:
October 3, 2016
Source:
Vanderbilt University Medical Center
Summary:
Human noroviruses are the leading cause of viral gastroenteritis. Worldwide, about 200,000 children under age 5 die from norovirus infections every year. As of yet, no vaccines or antiviral agents have been licensed to treat the disease. Now researchers have determined the structural basis for norovirus "neutralization" by a human IgA antibody.
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Human noroviruses are the leading cause of viral gastroenteritis. Worldwide, about 200,000 children under age 5 die from norovirus infections every year. As of yet, no vaccines or antiviral agents have been licensed to treat the disease.

Now researchers at Baylor College of Medicine and Vanderbilt University Medical Center, including James E. Crowe Jr., M.D., Gopal Sapparapu, Ph.D., and graduate student Gabriela Alvarado, have determined the structural basis for norovirus "neutralization" by a human IgA antibody.

In a paper published Sept. 19 in the Proceedings of the National Academy of Sciences, the researchers showed that the antibody prevents the virus from binding to histo-blood group antigens on the surfaces of cells in the gut. IgA antibodies play a critical role in immune function in mucous membranes.

Because viral binding sites are hypervariable, it may be difficult to generate "broadly reactive" antibodies against them. A solution might be to develop methods that specifically target highly conserved binding sites, the researchers concluded.


Story Source:

Materials provided by Vanderbilt University Medical Center. Original written by Bill Snyder. Note: Content may be edited for style and length.


Journal Reference:

  1. Sreejesh Shanker, Rita Czakó, Gopal Sapparapu, Gabriela Alvarado, Maria Viskovska, Banumathi Sankaran, Robert L. Atmar, James E. Crowe, Mary K. Estes, B. V. Venkataram Prasad. Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proceedings of the National Academy of Sciences, 2016; 201609990 DOI: 10.1073/pnas.1609990113

Cite This Page:

Vanderbilt University Medical Center. "Targeting norovirus 'noxiousness'." ScienceDaily. ScienceDaily, 3 October 2016. <www.sciencedaily.com/releases/2016/10/161003131034.htm>.
Vanderbilt University Medical Center. (2016, October 3). Targeting norovirus 'noxiousness'. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/10/161003131034.htm
Vanderbilt University Medical Center. "Targeting norovirus 'noxiousness'." ScienceDaily. www.sciencedaily.com/releases/2016/10/161003131034.htm (accessed May 24, 2017).

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