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Enzyme is crucial for combatting antibiotic-resistant E. coli infections

Date:
October 27, 2016
Source:
University of Kent
Summary:
New research is expected to pave the way for new approaches to kill bacteria that no longer respond to conventional antibiotics.
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Cytochrome bd-I tagged with Green Fluorescent Protein can be visualized in the membrane of E. coli.
Credit: Dr Mark Shepherd

Research by bioscientists at the University of Kent and the University of Queensland is expected to pave the way for new approaches to kill bacteria that no longer respond to conventional antibiotics.

In a paper published by Scientific Reports, Kent's Dr Mark Shepherd and colleagues demonstrate the importance of an enzyme, cytochrome bd-I, for survival of E. coli that is resistant to multiple antibiotics.

E. coli causes serious conditions including sepsis, bladder infections, kidney failure, and dysentery. The human immune system produces nitric oxide to kill invading E. coli, and cytochrome bd-I is shown to provide significant resistance to nitric oxide during infection.

Since cytochrome bd-I is absent in humans, drugs designed to target this enzyme are less likely to be toxic to human cells. In future, targeting cytochrome bd-I with new drugs will render antibiotic-resistant bacteria more susceptible to attack from the host immune system.


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Materials provided by University of Kent. Note: Content may be edited for style and length.


Journal Reference:

  1. Mark Shepherd, Maud E. S. Achard, Adi Idris, Makrina Totsika, Minh-Duy Phan, Kate M. Peters, Sohinee Sarkar, Cláudia A. Ribeiro, Louise V. Holyoake, Dimitrios Ladakis, Glen C. Ulett, Matthew J. Sweet, Robert K. Poole, Alastair G. McEwan, Mark A. Schembri. The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection. Scientific Reports, 2016; 6: 35285 DOI: 10.1038/srep35285

Cite This Page:

University of Kent. "Enzyme is crucial for combatting antibiotic-resistant E. coli infections." ScienceDaily. ScienceDaily, 27 October 2016. <www.sciencedaily.com/releases/2016/10/161027123120.htm>.
University of Kent. (2016, October 27). Enzyme is crucial for combatting antibiotic-resistant E. coli infections. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2016/10/161027123120.htm
University of Kent. "Enzyme is crucial for combatting antibiotic-resistant E. coli infections." ScienceDaily. www.sciencedaily.com/releases/2016/10/161027123120.htm (accessed May 27, 2017).

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