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Skin sodium content linked to heart problems in patients with kidney disease

Date:
February 3, 2017
Source:
American Society of Nephrology (ASN)
Summary:
Elevated sodium content in the skin correlates closely with left ventricular hypertrophy in patients with chronic kidney disease, report researchers.
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New research may provide insights concerning the cause of changes in the heart's structure that often occur in patients with chronic kidney disease (CKD). The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that treatments targeting skin sodium may help protect CKD patients' heart health.

Individuals with CKD are at elevated risk of developing heart problems and dying from cardiovascular causes. At least in part, these increased risks are related to a high prevalence and severity of left ventricular hypertrophy (LVH), an enlargement and thickening of the walls of the heart's left ventricle. The cause of LVH in patients with CKD is unclear, although some studies suggest that excess sodium intake may play a role.

Recent research indicates that tissues such as skin and muscle may store sodium. Markus Schneider, MD (University of Erlangen-Nuremberg, in Germany) and his colleagues wondered whether sodium deposition in these newly identified sodium stores is related to the degree of LVH in CKD patients. Using a technique called 23Na-magnetic resonance imaging, the team measured skin sodium content at the level of the calf in 99 patients with mild to moderate CKD. The researchers also assessed total body water levels, 24-hour blood pressure, and left ventricular mass.

Skin sodium content, but not total body water, correlated with systolic blood pressure. Moreover, skin sodium content correlated more strongly than total body water did with left ventricular mass. Results from additional analyses suggested that skin sodium is a strong explanatory variable of left ventricular mass independent of blood pressure or total body water.

"We believe that skin sodium reflects deposition of excess sodium," said Dr. Schneider. "Our finding of a strong relationship between skin sodium and changes in the structure of the heart suggests that interventions that reduce skin sodium content -- for example dietary sodium restriction or medications that lead to increased sodium excretion -- may have beneficial effects on the heart in patients with kidney disease."


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Materials provided by American Society of Nephrology (ASN). Note: Content may be edited for style and length.


Journal Reference:

  1. Markus P. Schneider, Ulrike Raff, Christoph Kopp, Johannes B. Scheppach, Sebastian Toncar, Christoph Wanner, Georg Schlieper, Turgay Saritas, Jürgen Floege, Matthias Schmid, Anna Birukov, Anke Dahlmann, Peter Linz, Rolf Janka, Michael Uder, Roland E. Schmieder, Jens M. Titze, Kai-Uwe Eckardt. Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD. Journal of the American Society of Nephrology, 2017; ASN.2016060662 DOI: 10.1681/ASN.2016060662

Cite This Page:

American Society of Nephrology (ASN). "Skin sodium content linked to heart problems in patients with kidney disease." ScienceDaily. ScienceDaily, 3 February 2017. <www.sciencedaily.com/releases/2017/02/170203103430.htm>.
American Society of Nephrology (ASN). (2017, February 3). Skin sodium content linked to heart problems in patients with kidney disease. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2017/02/170203103430.htm
American Society of Nephrology (ASN). "Skin sodium content linked to heart problems in patients with kidney disease." ScienceDaily. www.sciencedaily.com/releases/2017/02/170203103430.htm (accessed May 27, 2017).

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