Science News
from research organizations

Enlarged prostate later in life could stem from fetal development early on

Date:
March 13, 2017
Source:
Michigan State University
Summary:
Embryonic tissue, key to the development of a baby’s gender, could contribute to an enlarged prostate, or BPH, in men later in life, new research suggests.
Share:
FULL STORY

New research from Michigan State University indicates that embryonic tissue, key to the development of a baby's gender, could contribute to an enlarged prostate, or BPH, in men later in life.

It's estimated that up to 90 percent of older men experience BPH, or benign prostatic hyperplasia, and quality of life can be severely affected.

"During development, both male and female embryos start out having certain fetal tissue called the Müllerian duct mesenchyme," said Jose Teixeira, professor of reproductive biology in the College of Human Medicine and lead author of the federally funded study. "Human male embryos need to get rid of this tissue typically between 7 to 10 weeks after conception or else they will develop a uterus."

According to Teixeira, his latest findings, now published in PNAS, clearly show that some of this tissue remains in male mice and contributes to cells where the prostate is located.

"No one really has known the origin of this disease," Teixeira said. "But we now have early clues that this remnant tissue in the mice becomes part of the tissue that would go on to develop an enlarged prostate."

Teixeira and his team also found that a malfunctioning tumor-suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

"By altering the Stk11 gene, the number of cells in this embryonic tissue multiplied above what is needed and caused the prostate tissue surrounding the urethra to grow," Teixeira said.

This overgrowth of tissue is what he indicated could cause the lower urinary tract symptoms, such as difficulty urinating, in older men with the disease.

"Most drugs or procedures on the market today just treat the symptoms, not the disease itself," Teixeira said. "Our study could open up a whole new pathway for targeted treatments to help shrink the prostate tissue or stop it from growing further."

Before this can happen though, Teixeira said that his team will first have to determine whether the Stk11 gene or the other genes and proteins it controls are similarly affected in the human form of BPH.


Story Source:

Materials provided by Michigan State University. Note: Content may be edited for style and length.


Journal Reference:

  1. Jitu W. George, Amanda L. Patterson, Pradeep S. Tanwar, André Kajdacsy-Balla, Gail S. Prins, Jose M. Teixeira. Specific deletion of LKB1/ Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice. Proceedings of the National Academy of Sciences, 2017; 201612284 DOI: 10.1073/pnas.1612284114

Cite This Page:

Michigan State University. "Enlarged prostate later in life could stem from fetal development early on." ScienceDaily. ScienceDaily, 13 March 2017. <www.sciencedaily.com/releases/2017/03/170313192731.htm>.
Michigan State University. (2017, March 13). Enlarged prostate later in life could stem from fetal development early on. ScienceDaily. Retrieved March 27, 2017 from www.sciencedaily.com/releases/2017/03/170313192731.htm
Michigan State University. "Enlarged prostate later in life could stem from fetal development early on." ScienceDaily. www.sciencedaily.com/releases/2017/03/170313192731.htm (accessed March 27, 2017).