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Administration of steroid to extremely preterm infants not associated with adverse effects on neurodevelopment

Date:
April 4, 2017
Source:
The JAMA Network Journals
Summary:
The administration of low-dose hydrocortisone to extremely preterm infants was not associated with any adverse effects on neurodevelopmental outcomes at 2 years of age, according to a study.
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The administration of low-dose hydrocortisone to extremely preterm infants was not associated with any adverse effects on neurodevelopmental outcomes at 2 years of age, according to a study published by JAMA.

Early low-dose hydrocortisone treatment in very preterm infants has been reported to improve survival without bronchopulmonary dysplasia (a form of chronic lung disease), but its safety with regard to neurodevelopment remains to be assessed. Olivier Baud, M.D., Ph.D., of Robert Debre Children's Hospital, Paris, and colleagues analyzed data from the PREMILOC trial, in which infants born between 24 0/7 weeks and 27 6/7 weeks of gestation and before 24 hours of postnatal age were randomly assigned to receive either placebo or low-dose hydrocortisone injection.

Of neonates screened, 523 were assigned to hydrocortisone (n = 256) or placebo (n = 267) and 406 survived to 2 years of age. A total of 379 patients (93 percent) were evaluated at a median corrected age of 22 months. The researchers found no statistically significant difference in patients without neurodevelopmental impairment (73 percent in the hydrocortisone group vs 70 percent in the placebo group), with mild neurodevelopmental impairment (20 percent in the hydrocortisone group vs 18 percent in the placebo group), or with moderate to severe neurodevelopmental impairment (7 percent in the hydrocortisone group vs 11 percent in the placebo group). The incidence of cerebral palsy or other major neurological impairments was not significantly different between groups.

"Further randomized studies are needed to provide definitive assessment of the neurodevelopmental safety of hydrocortisone in extremely preterm infants," the authors write.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Olivier Baud, MD, PhD et al. Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age. JAMA, April 2017 DOI: 10.1001/jama.2017.2692

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The JAMA Network Journals. "Administration of steroid to extremely preterm infants not associated with adverse effects on neurodevelopment." ScienceDaily. ScienceDaily, 4 April 2017. <www.sciencedaily.com/releases/2017/04/170404160134.htm>.
The JAMA Network Journals. (2017, April 4). Administration of steroid to extremely preterm infants not associated with adverse effects on neurodevelopment. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2017/04/170404160134.htm
The JAMA Network Journals. "Administration of steroid to extremely preterm infants not associated with adverse effects on neurodevelopment." ScienceDaily. www.sciencedaily.com/releases/2017/04/170404160134.htm (accessed May 28, 2017).

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