New! Sign up for our free email newsletter.
Science News
from research organizations

Tumor cells get stiff before becoming invasive

Date:
May 16, 2017
Source:
Instituto Gulbenkian de Ciencia
Summary:
Breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. The discovery identifies a new signal in tumor cells that can be further explored when designing cancer-targeting therapies.
Share:
FULL STORY

A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. The discovery made by a research team led by Florence Janody, from Instituto Gulbenkian de Ciencia (IGC; Portugal), identifies a new signal in tumor cells that can be further explored when designing cancer-targeting therapies.

The progression of breast cancer disease takes several stages, from a benign lesion to an invasive carcinoma, possibly with metastasis. But actually, only 20 to 50% of benign tumors end up as invasive cancer. Predicting what lesions are within this group could result in a better use of therapeutics accordingly to the severity of the disease.

Florence Janody's group has been looking for signals inside the cells that could help predicting benign tumors that will progress to invasive carcinoma. Their attention focus on the cell skeleton -- the cytoskeleton -- , an intricate network of fibers that can either exert or resist forces, and that may have an impact on tumor invasion and malignancy. These fibers can be organized into distinct architectures to confer cells a more rigid or soft structure.

"Previously, it had been shown that cancer cell invasion requires cell softening. What we observed now is that prior to becoming invasive cells undergo a transient stiffening state caused by the accumulation of cytoskeleton fibers ," explains Sandra Tavares, first author of this study.

The research team discovered that cell stiffening induces the activity of proteins that promote cell proliferation, driving the growth of benign tumors. Most importantly, this cell rigidity state also triggers the subsequent progression into invasive cancer. The proteins involved in this mechanism were identified by studies on a human breast cell line, which recapitulates the multistep development of breast cancer, and biopsies of breast cancers. The importance of these proteins for the formation of tumors was further confirmed in the fruit fly.

Florence Janody says: "Our work adds an important piece to the intricate puzzle of breast tumor progression. Knowing what happens inside the cell before a cell becomes pre-invasive and acquires malignant features may help us predict, in the future, which tumors may result in metastasis. Also, it may help designing therapeutics better tailored for each type of lesion."


Story Source:

Materials provided by Instituto Gulbenkian de Ciencia. Note: Content may be edited for style and length.


Journal Reference:

  1. Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B. Pereira-Leal, Jochen Guck, Joana Paredes, Florence Janody. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells. Nature Communications, 2017; 8: 15237 DOI: 10.1038/NCOMMS15237

Cite This Page:

Instituto Gulbenkian de Ciencia. "Tumor cells get stiff before becoming invasive." ScienceDaily. ScienceDaily, 16 May 2017. <www.sciencedaily.com/releases/2017/05/170516080759.htm>.
Instituto Gulbenkian de Ciencia. (2017, May 16). Tumor cells get stiff before becoming invasive. ScienceDaily. Retrieved November 6, 2024 from www.sciencedaily.com/releases/2017/05/170516080759.htm
Instituto Gulbenkian de Ciencia. "Tumor cells get stiff before becoming invasive." ScienceDaily. www.sciencedaily.com/releases/2017/05/170516080759.htm (accessed November 6, 2024).

Explore More

from ScienceDaily

RELATED STORIES