New! Sign up for our free email newsletter.
Science News
from research organizations

Behavioral approach reduces cognitive fatigue in multiple sclerosis, study shows

Novel study demonstrated potential for nonpharmacologic intervention for treating cognitive fatigue in individuals with multiple sclerosis

Date:
September 20, 2017
Source:
Kessler Foundation
Summary:
Multiple sclerosis researchers describe a new nonpharmacological approach to reducing cognitive fatigue in MS. Using functional neuroimaging, they showed the prospect of monetary reward stimulates the fronto-striatal network and reduces cognitive fatigue in MS and controls. This is the first study to demonstrate this effect in an MS population.
Share:
FULL STORY

A recent article by MS researchers describes a new nonpharmacological approach to reduce cognitive fatigue, a disabling symptom reported by as many as 90% of individuals with multiple sclerosis (MS). Using functional neuroimaging, they demonstrated that the prospect of monetary reward stimulates the fronto-striatal network, resulting in the reduction of cognitive fatigue in individuals with MS and healthy controls. This is the first study to demonstrate this effect in an MS population.

The article, "Fronto-striatal network activation leads to less fatigue in multiple sclerosis" was published online on June 19, 2017, in Multiple Sclerosis Journal. The authors are Ekaterina Dobryakova, PhD, Angela Spirou, MS, Nancy Chiaravalloti, PhD, Helen Genova, PhD, Glenn Wylie, DPhil, and John DeLuca, PhD, of Kessler Foundation, and Hanneke Hulst, PhD, of VU University Medical Center, Amsterdam, The Netherlands.

Studies show that the fronto-striatal network is involved in cognitive fatigue, which can be modulated by both pharmacological andnon pharmacological interventions. In this study, investigators examined the effects of a nonpharmacological intervention in 14 healthy controls and 19 individuals with MS. All participants underwent functional MRI while performing a gambling task. They were tested under two conditions: 'outcome' and 'no outcome'. For the outcome condition, they were offered the opportunity to win a monetary reward; for the no outcome condition, no reward was offered.

"We found significant differences in activation between the two conditions in both groups," said Dr. Dobryakova, the lead author. "With the outcome condition, significant activation of the frontostriatal network was associated with significant reduction in fatigue, suggesting that behavioral interventions that motivate individuals to reach a particular goal may be an effective approach to reducing fatigue. These findings show that there's potential for treating cognitive fatigue in MS with noninvasive interventions that provide a goal, such as winning money (as in the current study), for example, or achieving a good score on a test."

Dr. Dobryakova, a research scientist at Kessler Foundation, was a recipient of a 2016 Switzer Research Fellowship by the National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR), and a 2015 Independent Investigator Grant from the National MS Society.

This research was supported by the National MS Society (RG 1501-02630) and Kessler Foundation. Kessler researchers and clinicians have faculty appointments in the department of Physical Medicine and Rehabilitation at Rutgers New Jersey Medical School.


Story Source:

Materials provided by Kessler Foundation. Note: Content may be edited for style and length.


Journal Reference:

  1. Ekaterina Dobryakova, Hanneke E Hulst, Angela Spirou, Nancy D Chiaravalloti, Helen M Genova, Glenn R Wylie, John DeLuca. Fronto-striatal network activation leads to less fatigue in multiple sclerosis. Multiple Sclerosis Journal, 2017; 135245851771708 DOI: 10.1177/1352458517717087

Cite This Page:

Kessler Foundation. "Behavioral approach reduces cognitive fatigue in multiple sclerosis, study shows." ScienceDaily. ScienceDaily, 20 September 2017. <www.sciencedaily.com/releases/2017/09/170920115306.htm>.
Kessler Foundation. (2017, September 20). Behavioral approach reduces cognitive fatigue in multiple sclerosis, study shows. ScienceDaily. Retrieved July 24, 2024 from www.sciencedaily.com/releases/2017/09/170920115306.htm
Kessler Foundation. "Behavioral approach reduces cognitive fatigue in multiple sclerosis, study shows." ScienceDaily. www.sciencedaily.com/releases/2017/09/170920115306.htm (accessed July 24, 2024).

Explore More

from ScienceDaily

RELATED STORIES