New! Sign up for our free email newsletter.
Science News
from research organizations

Could statins ease deadly heart condition in rare neuromuscular disease?

Study shows that cholesterol drug may help Friedreich's ataxia patients

Date:
April 17, 2018
Source:
University of Pennsylvania School of Medicine
Summary:
Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects. In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein).
Share:
FULL STORY

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the "good cholesterol," according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Decreased HDL and apolipoprotein A-I (ApoA-l) levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. "We found the FA patients had serum ApoA-I levels that were lower than healthy control subjects," said senior author Ian Blair, PhD, a professor of Systems Pharmacology and Translational Therapeutics. The next step of the research, conducted in collaboration with David Lynch, MD, PhD, a professor of Neurology at Children's Hospital of Philadelphia (CHOP), showed that statins may be able to help Friedreich's ataxia patients increase their naturally low ApoA-I levels and so increase their HDL levels, which might help prevent heart disease.

Friedreich's ataxia (FA) is a rare condition diagnosed in about in 50,000 people worldwide. It is the most common form of inherited ataxia, a condition characterized by a progressive loss of coordinated movement and balance. Onset of symptoms usually occurs in childhood, and most patients are confined to a wheelchair by their mid-to-late twenties. Most FA patients die from the thickening of their heart walls (hypertrophic cardiomyopathy) rather than from neurological issues.

In FA, the protein frataxin is made in insufficient amounts for mitochondria to function properly. This happens because of a mutation in the FXN gene, which results in reduced expression of frataxin protein. Frataxin is normally found in the mitochondria of cells and is involved in biochemical reactions that produce energy.

Using a highly specific and sensitive assay, the researchers found a 22 percent decrease in ApoA-I in the blood of FA patients compared with blood samples from non-affected healthy individuals. Using an experimental FA cell line, they also found that cells without frataxin produced lower levels of ApoA-I compared to controls. However, the cholesterol-lowering drug simvastatin increased the ApoA-I levels by 20 percent in these cells.

"I think that our findings provide compelling evidence for a trial of statins in FA patients to potentially reduce their cardiovascular risk," Blair said. One issue is that higher doses of statins are associated with myositis (muscle inflammation) and rhabdomyolysis (destruction of skeletal muscle) so it would be essential to carefully monitor these side effects, he noted. In addition, co-administration of coenzyme Q10 supplement could help reduce the risk of muscle-related side effects.

Overall, Blair maintains that the potential benefits to FA patients with low ApoA-I levels taking low doses of statins outweigh the potential risks.

This research was funded by the Penn Medicine/CHOP Friedreich's Ataxia Center of Excellence, in partnership with the Hamilton and Finneran families.


Story Source:

Materials provided by University of Pennsylvania School of Medicine. Note: Content may be edited for style and length.


Journal Reference:

  1. QingQing Wang, Lili Guo, Cassandra J. Strawser, Lauren A. Hauser, Wei-Ting Hwang, Nathaniel W. Snyder, David R. Lynch, Clementina Mesaros, Ian A. Blair. Low apolipoprotein A-I levels in Friedreich’s ataxia and in frataxin-deficient cells: Implications for therapy. PLOS ONE, 2018; 13 (2): e0192779 DOI: 10.1371/journal.pone.0192779

Cite This Page:

University of Pennsylvania School of Medicine. "Could statins ease deadly heart condition in rare neuromuscular disease?." ScienceDaily. ScienceDaily, 17 April 2018. <www.sciencedaily.com/releases/2018/04/180417115802.htm>.
University of Pennsylvania School of Medicine. (2018, April 17). Could statins ease deadly heart condition in rare neuromuscular disease?. ScienceDaily. Retrieved May 17, 2024 from www.sciencedaily.com/releases/2018/04/180417115802.htm
University of Pennsylvania School of Medicine. "Could statins ease deadly heart condition in rare neuromuscular disease?." ScienceDaily. www.sciencedaily.com/releases/2018/04/180417115802.htm (accessed May 17, 2024).

Explore More

from ScienceDaily

RELATED STORIES