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Antibiotics destroy 'good bacteria' and worsen oral infection

Date:
September 26, 2018
Source:
Case Western Reserve University
Summary:
Researchers found that antibiotics actually kill the 'good' bacteria keeping infection and inflammation at bay.
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New research shows that the body's own microbes are effective in maintaining immune cells and killing certain oral infections.

A team of Case Western Reserve University researchers found that antibiotics actually kill the "good" bacteria keeping infection and inflammation at bay.

Scientists have long known that overuse of antibiotics can do more harm than good. For example, overuse can cause antibiotic resistance. But research into this phenomenon in oral health was uncharted territory.

Pushpa Pandiyan, an assistant professor of biological sciences in the School of Dental Medicine, led a team of researchers to examine "resident" bacteria, their fatty acids and their effect on certain types of white blood cells that combat infections in the mouth.

Specifically, researchers looked at the "short-term maintenance" of Tregs and Th-17 cells in fighting fungal infections, such as Candida, in a laboratory setting.

They found that those natural defenses were very effective in reducing infection and unwanted inflammation -- and antibiotics can prevent such natural defenses. Their work was recently published in Frontiers in Microbiology.

"We set out to find out what happens when you don't have bacteria to fight a fungal infection," Pandiyan said. "What we found was that antibiotics can kill short-chain fatty acids produced by body's own good bacteria."

"We have good bacteria doing good work every day, why kill them?" Pandiyan added. "As is the case with many infections, if you leave them alone, they will leave on their own."

"Of course, antibiotics are still needed for life threatening infections. No question about that. Our bodies have many natural defenses that we shouldn't meddle with," she said. However, needless overuse of antibiotics is not helpful, she said.

"Also, we know there is a definite link between oral health and overall health," she added.

Pandiyan said the study could have broader implications on protective effects of "resident microbiota" in other types of infections.

Pandiyan is concurrently working on a National Institutes of Health research project examining HIV patients who have developed oral-health conditions as a result of weakened immune systems.

She was joined in the study by dental school research staff Natarajan Bhaskaran, Cheriese Quigley, and Elizabeth Schneider, and students Clarissa Paw and Shivani Butala.


Story Source:

Materials provided by Case Western Reserve University. Note: Content may be edited for style and length.


Journal Reference:

  1. Natarajan Bhaskaran, Cheriese Quigley, Clarissa Paw, Shivani Butala, Elizabeth Schneider, Pushpa Pandiyan. Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection. Frontiers in Microbiology, 2018; 9 DOI: 10.3389/fmicb.2018.01995

Cite This Page:

Case Western Reserve University. "Antibiotics destroy 'good bacteria' and worsen oral infection." ScienceDaily. ScienceDaily, 26 September 2018. <www.sciencedaily.com/releases/2018/09/180926082539.htm>.
Case Western Reserve University. (2018, September 26). Antibiotics destroy 'good bacteria' and worsen oral infection. ScienceDaily. Retrieved February 29, 2024 from www.sciencedaily.com/releases/2018/09/180926082539.htm
Case Western Reserve University. "Antibiotics destroy 'good bacteria' and worsen oral infection." ScienceDaily. www.sciencedaily.com/releases/2018/09/180926082539.htm (accessed February 29, 2024).

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