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Gravity changes mass of muscles and bones, experiments in space show

Date:
July 25, 2019
Source:
Tokyo University of Agriculture and Technology
Summary:
Researchers have found that bone and muscle mass are regulated by the altered gravity. The experiments were done in space using Kibo, an ISS module developed by JAXA, and on the ground.
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An international collaboration led by scientists mainly at Tokyo University of Agriculture and Technology (TUAT) , Japan, has found that bone and muscle mass are regulated by the altered gravity. The experiments were done in space using Kibo, a ISS module developed by JAXA, and on the ground.

The researchers published their results on April 29th in the journal, Scientific Reports.

The research team explored the maintenance of the bone and muscle mass of mice among the opposite living circumstances of microgravity and hypergravity. "We examined the effects of 2G hypergravity on the ground and artificial 1G gravity in space for the effect of bone and muscle mass using newly developed centrifuge devices," said Dr Masaki Inada, corresponding author on the paper and Associate Professor in the Department of Biotechnology and Life Science, Institute of Global Innovation Research at TUAT.

The team found that changing gravity with a physical load of own body weight altered the bone mass of forefoot (humerus) especially in fourth-foot walk animals (tetrapods) such as mice. For example, lower gravity, which was in space, showed loss in some bones such as the humerus and tibia. In addition, more gravity, which was in 2G on the ground artificially created by the centrifuge device, made more muscle such as the lower leg muscles (muscles from knee to ankle).

"Then we continuously examine to find the mechano-sensing factors regulated by mechanical stress in the mice for altered living circumstances of the gravity," said Dr Inada. "To find forth dependent mechano-sensor results in controlling bone and muscle mass could be applied for novel drug development for the bone and muscle of skeletal diseases with disuse ability such as sarcopenia and osteoporosis."


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Materials provided by Tokyo University of Agriculture and Technology. Note: Content may be edited for style and length.


Journal Reference:

  1. Tsukasa Tominari, Ryota Ichimaru, Keita Taniguchi, Akane Yumoto, Masaki Shirakawa, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Yoshifumi Itoh, Dai Shiba, Chisato Miyaura, Masaki Inada. Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-42829-z

Cite This Page:

Tokyo University of Agriculture and Technology. "Gravity changes mass of muscles and bones, experiments in space show." ScienceDaily. ScienceDaily, 25 July 2019. <www.sciencedaily.com/releases/2019/07/190725100501.htm>.
Tokyo University of Agriculture and Technology. (2019, July 25). Gravity changes mass of muscles and bones, experiments in space show. ScienceDaily. Retrieved June 24, 2024 from www.sciencedaily.com/releases/2019/07/190725100501.htm
Tokyo University of Agriculture and Technology. "Gravity changes mass of muscles and bones, experiments in space show." ScienceDaily. www.sciencedaily.com/releases/2019/07/190725100501.htm (accessed June 24, 2024).

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