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Repurposed antibiotic may be an effective therapeutic in COVID-19 infected mice

Study suggests Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology

Date:
May 19, 2022
Source:
PLOS
Summary:
Repurposed drugs may have a speedier path to clinical use because they have already been shown to be safe in people. A new study suggests clofoctol may be an effective treatment for SARS-CoV-2 infections in mice.
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Repurposed drugs may have a speedier path to clinical use because they have already been shown to be safe in people. A study publishing May 19in the open access journal PLOS Pathogens by Sandrine Belouzard and Jean Dubuisson at Pasteur Institute, Lille, France and colleagues suggests clofoctol may be an effective treatment for SARS-CoV-2 infections in mice.

While COVID-19 vaccines reduce hospitalizations and death, they do not control virus transmission, and affordable, effective therapies are needed. Previous attempts to repurpose medicines to treat COVID-19 patients have been unsuccessful. In order to identify potential antiviral therapies effective against COVID-19, authors accessed the Apteeus drug library, a collection of 1,942 approved drugs to identify molecules that exhibit antiviral activity against SARS-CoV-2. The authors selected clofoctol based on its antiviral potency and tested their hypothesis by testing its effects in SARS-CoV-2-infected mice.

The researchers found that transgenic mice treated with clofoctol had a decreased viral load, reduced inflammatory gene expression, and lowered pulmonary pathology. Future studies are needed to further understand the drug's therapeutic potential in SARS-CoV-2 patients as the study was limited by the physiological differences between humans and mice. Additionally, the mice were sacrificed only two days after treatment, so longer-term effects remain unknown.

According to the authors, "The antiviral and anti-inflammatory properties of clofoctol, associated with its safety profile and unique pharmacokinetics make a strong case for proposing clofoctol as an affordable therapeutic candidate for the treatment of COVID-19 patients. Finally, the relatively low cost of this drug suggests that it is a potential clinical option for treatment of COVID-19 patients in resource-poor settings."

"Antivirals targeting SARS-CoV-2 are sorely needed," adds Dubuisson. "In this study, we screened a library of drug compounds and identified clofoctol as an antiviral against SARS-CoV-2. We further demonstrated that, in vivo, this compound reduces inflammatory gene expression and lowers pulmonary pathology and decreases viral load."


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Journal Reference:

  1. Sandrine Belouzard, Arnaud Machelart, Valentin Sencio, Thibaut Vausselin, Eik Hoffmann, Nathalie Deboosere, Yves Rouillé, Lowiese Desmarets, Karin Séron, Adeline Danneels, Cyril Robil, Loic Belloy, Camille Moreau, Catherine Piveteau, Alexandre Biela, Alexandre Vandeputte, Séverine Heumel, Lucie Deruyter, Julie Dumont, Florence Leroux, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober, Priscille Brodin, Terence Beghyn, François Trottein, Benoit Deprez, Jean Dubuisson. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice. PLOS Pathogens, 2022; 18 (5): e1010498 DOI: 10.1371/journal.ppat.1010498

Cite This Page:

PLOS. "Repurposed antibiotic may be an effective therapeutic in COVID-19 infected mice." ScienceDaily. ScienceDaily, 19 May 2022. <www.sciencedaily.com/releases/2022/05/220519141018.htm>.
PLOS. (2022, May 19). Repurposed antibiotic may be an effective therapeutic in COVID-19 infected mice. ScienceDaily. Retrieved May 23, 2024 from www.sciencedaily.com/releases/2022/05/220519141018.htm
PLOS. "Repurposed antibiotic may be an effective therapeutic in COVID-19 infected mice." ScienceDaily. www.sciencedaily.com/releases/2022/05/220519141018.htm (accessed May 23, 2024).

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