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Collagen a key player in breast cancer metastasis

The level of collagen type XII in breast tumors plays an important role in triggering the spread of cancer cells around the body

August 10, 2022
Garvan Institute of Medical Research
Collagen type XII plays a key role in regulating the organisation of the tumor matrix, reveals a new study.

Collagen type XII plays a key role in regulating the organisation of the tumour matrix, reveals a new study from the Garvan Institute of Medical Research. A team of scientists led by Associate Professor Thomas Cox, Head of the Matrix and Metastasis lab, also discovered that high levels of collagen XII can trigger breast cancer cells to spread from the tumour to other parts of the body, a process known as metastasis.

The tumour microenvironment is the ecosystem that surrounds a tumour, one component of which is the extracellular matrix. Cancer cells constantly interact with the tumour microenvironment, which affects how a tumour grows. Collagen is an important part of this tumour microenvironment, but just how it influences tumours has not been understood.

"There's still a lot we don't know about the role of the extracellular matrix in cancer metastasis. Our study shows that collagen XII plays an important role in breast cancer progression and metastasis," says senior author Associate Professor Thomas Cox.

"Imagine cancer cells as seeds, and the tumour microenvironment as the soil. By studying the soil -- the extracellular matrix -- we can begin to understand what makes some tumours more aggressive than others, and by extension, begin to develop new ways to treat cancer," he says.

The research also suggests that measuring the level of collagen XII in a patient's tumour biopsy could potentially be used as an additional screening tool to identify aggressive breast cancers with higher rates of metastasis, such as in the triple-negative type of breast cancer. Furthermore, collagen XII might be a possible target for future treatments.

The study is published in the journal Nature Communications.

Collagen XII alters tumour environment to help cancer cells invade

The extracellular matrix or 'matrix' is a 3D meshwork of around 300-400 core molecules, including several collagen proteins. This matrix provides structural and functional support to cells and tissues in all parts of the body.

In this study, the researchers catalogued how the tumour matrix changes over time and have generated a comprehensive database of these changes, which has been made freely available to researchers.

The team zeroed in on collagen XII, one of 28 types of collagen in the body. Collagen XII plays an important role in organising other collagens and can have profound effects on the 3D structure of the extracellular matrix.

The researchers studied tumours in mouse models from the earliest pre-clinical stages of cancer, right through to late-stage tumours. They found that as the tumours developed, many matrix molecules changed, and importantly the level of collagen XII was also increased.

"Collagen XII seems to be altering the properties of the tumour and makes it more aggressive," says first author Michael Papanicolaou, from Garvan. "It changes how collagens are organised to support cancer cells escaping from the tumour and moving to other sites like the lungs."

The team then used genetic engineering to manipulate production of collagen XII, and looked at the effects of metastasis to other organs. They found that as levels of collagen XII increased, so did metastasis. These findings were then confirmed in human tumour biopsies, which showed that high levels of collagen XII are associated with higher metastasis and poorer overall survival rates.

Further research will focus on studying more human samples, and investigating possible therapeutic pathways.

Story Source:

Materials provided by Garvan Institute of Medical Research. Note: Content may be edited for style and length.

Journal Reference:

  1. Michael Papanicolaou, Amelia L. Parker, Michelle Yam, Elysse C. Filipe, Sunny Z. Wu, Jessica L. Chitty, Kaitlin Wyllie, Emmi Tran, Ellie Mok, Audrey Nadalini, Joanna N. Skhinas, Morghan C. Lucas, David Herrmann, Max Nobis, Brooke A. Pereira, Andrew M. K. Law, Lesley Castillo, Kendelle J. Murphy, Anaiis Zaratzian, Jordan F. Hastings, David R. Croucher, Elgene Lim, Brian G. Oliver, Fatima Valdes Mora, Benjamin L. Parker, David Gallego-Ortega, Alexander Swarbrick, Sandra O’Toole, Paul Timpson, Thomas R. Cox. Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32255-7

Cite This Page:

Garvan Institute of Medical Research. "Collagen a key player in breast cancer metastasis." ScienceDaily. ScienceDaily, 10 August 2022. <>.
Garvan Institute of Medical Research. (2022, August 10). Collagen a key player in breast cancer metastasis. ScienceDaily. Retrieved April 16, 2024 from
Garvan Institute of Medical Research. "Collagen a key player in breast cancer metastasis." ScienceDaily. (accessed April 16, 2024).

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