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One-step synthesis of the most common, yet highly intricate, antibiotic molecular scaffold

Date:
January 16, 2024
Source:
Osaka University
Summary:
Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes the toxicity that is a common feature of similar Fischer-carbene synthetic methodologies, and was used to synthesize the scaffold of the thienamycin antibiotic in high yield. This work is an important advancement in sustainable chemistry that should benefit drug development and other chemical syntheses.
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While we appear to live in a world of plenty, behind the scenes, sourcing sufficient amounts of key ingredients can be challenging. For example, the synthesis of certain antibiotics, beta-lactam antibiotics, requires certain molecules in large quantities, and getting enough of these molecules has historically been difficult.

Now, in a study recently published in Nature Catalysis, researchers from Osaka University have unveiled a new, simplified way to synthesize the intricate beta-lactam scaffold that is characteristic of beta-lactam antibiotics.

Penicillin, the first mass-produced antibiotic, is an example of a beta-lactam antibiotic. These antibiotics are the first choice for certain bacterial infections because they are more selective and less toxic than most drugs. Unsurprisingly, there are dozens of beta-lactam antibiotics approved for clinical use and under development.

Unfortunately, synthesizing these antibiotics in the laboratory has been challenging owing to their small but intricate structure. Thus, catalysts are typically needed to facilitate critical steps during synthesis. One catalyst, known as a Fischer-carbene complex, works well but needs to be used in large quantities. The synthesis of a Fischer-carbene catalyst that works in small quantities was the goal of the research team's study.

"Our new catalytic system can generate Fischer-carbene complexes from organosilicon compounds, which are non-toxic," explains Tetsuya Inagaki, lead author of the study. "What's more, we were able to isolate and characterize a key intermediate: a siloxycarbene-palladium complex."

Unlike previous Fischer-carbene synthetic protocols, the process does not result in toxic chromium waste and does not require photo-irradiation. The reaction proceeds in just one step, is operationally straightforward, and requires only a small quantity of catalyst. The researchers used it to prepare the scaffold of the thienamycin antibiotic in 94% yield.

"We're excited because our research will help synthesize Fischer-carbene catalysts that are otherwise difficult to isolate, and provide access to structurally complicated beta-lactam building blocks in one reaction vessel," says Mamoru Tobisu, senior author. "We look forward to applying our reaction protocol to other classes of synthetic targets."

This work is an important step forward in simplifying the synthesis of beta-lactams, the most common molecular scaffold of antibiotics. Because the synthetic protocol is simple and minimally toxic, applications to further chemical transformations should be straightforward.


Story Source:

Materials provided by Osaka University. Note: Content may be edited for style and length.


Journal Reference:

  1. Tetsuya Inagaki, Takuya Kodama, Mamoru Tobisu. Catalytic synthesis of β-lactam derivatives by carbonylative cycloaddition of acylsilanes with imines via a palladium Fischer-carbene intermediate. Nature Catalysis, 2024; DOI: 10.1038/s41929-023-01081-5

Cite This Page:

Osaka University. "One-step synthesis of the most common, yet highly intricate, antibiotic molecular scaffold." ScienceDaily. ScienceDaily, 16 January 2024. <www.sciencedaily.com/releases/2024/01/240116131717.htm>.
Osaka University. (2024, January 16). One-step synthesis of the most common, yet highly intricate, antibiotic molecular scaffold. ScienceDaily. Retrieved March 2, 2024 from www.sciencedaily.com/releases/2024/01/240116131717.htm
Osaka University. "One-step synthesis of the most common, yet highly intricate, antibiotic molecular scaffold." ScienceDaily. www.sciencedaily.com/releases/2024/01/240116131717.htm (accessed March 2, 2024).

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