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Changes in flu circulation means U.S. likely to see vaccines move from quadrivalent to trivalent

Date:
February 29, 2024
Source:
University of Michigan
Summary:
U.S. flu vaccines are likely to move from quadrivalent to trivalent due to a change in circulating influenza viruses, according to a new paper.
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U.S. flu vaccines are likely to move from quadrivalent to trivalent due to a change in circulating influenza viruses, says a University of Michigan researcher.

Currently, all influenza vaccines in the United States are quadrivalent, meaning that they protect against four different flu viruses.

In a new paper published in the New England Journal of Medicine, researchers detail the spread of influenza B/Yamagata virus, which has not been in circulation since early 2020; the regulatory discussions and recommendations on updating vaccines; and the manufacturing considerations for new vaccine formulations for the U.S. and abroad.

"The removal of B/Yamagata virus is logical as we do not want to include a virus in vaccine formulation that is no longer in circulation," said Arnold Monto, professor emeritus of epidemiology and global public health at the U-M School of Public Health.

"It also gives us the space to replace B/Yamagata virus with a component that will give improved protection against the circulating influenza viruses. That will take additional studies to accomplish."

Monto has dedicated his career to researching the occurrence, prevention and control of respiratory infections. He also serves as a member of the U.S. Food and Drug Administration's Vaccines and Related Biological Products Advisory Committee.

Co-authors include Maria Zambon of the U.K. Health Security Agency and Jerry Weir of the Division of Viral Products, Center for Biologics Evaluation and Research at the U.S. Food and Drug Administration.


Story Source:

Materials provided by University of Michigan. Original written by Destiny Cook, U-M School of Public Health. Note: Content may be edited for style and length.


Journal Reference:

  1. Arnold S. Monto, Maria Zambon, Jerry P. Weir. The End of B/Yamagata Influenza Transmission — Transitioning from Quadrivalent Vaccines. New England Journal of Medicine, 2024; DOI: 10.1056/NEJMp2314801

Cite This Page:

University of Michigan. "Changes in flu circulation means U.S. likely to see vaccines move from quadrivalent to trivalent." ScienceDaily. ScienceDaily, 29 February 2024. <www.sciencedaily.com/releases/2024/02/240229124500.htm>.
University of Michigan. (2024, February 29). Changes in flu circulation means U.S. likely to see vaccines move from quadrivalent to trivalent. ScienceDaily. Retrieved April 15, 2024 from www.sciencedaily.com/releases/2024/02/240229124500.htm
University of Michigan. "Changes in flu circulation means U.S. likely to see vaccines move from quadrivalent to trivalent." ScienceDaily. www.sciencedaily.com/releases/2024/02/240229124500.htm (accessed April 15, 2024).

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