Featured Research

from universities, journals, and other organizations

Oregon Health Sciences University Researchers Take Steps To Genetically Modify Monkeys For The Research Of Human Disease

Date:
December 24, 1999
Source:
Oregon Health Sciences University
Summary:
Researchers at Oregon Health Sciences University report dramatic progress toward establishing genetically modified, non-human primate models for the study of causes and cures for human disease. Scientists were able to do this by perfecting a technique called TransgenICSI, which has allowed them to introduce new genetic information into the eggs of monkeys.

Portland Ore. -- Researchers at Oregon Health Sciences University report dramatic progress toward establishing genetically modified, non-human primate models for the study of causes and cures for human disease. Scientists were able to do this by perfecting a technique called TransgenICSI, which has allowed them to introduce new genetic information into the eggs of monkeys. The research was conducted by Anthony Chan, Ph.D., a staff scientist at OHSU's Oregon Regional Primate Research Center, and colleagues in a lab coordinated by Gerald Schatten, Ph.D., professor of obstetrics and gynecology, and cell and developmental biology in the OHSU School of Medicine. Their findings are printed in the latest issue of Molecular Human Reproduction.

Related Articles


Currently, genetically modified or transgenic mice are used by researchers for investigations into the molecular basis of diseases such as Alzheimer's, cystic fibrosis, diabetes and muscular dystrophy. However, many researchers agree mice are not perfect model systems to investigate human disorders. This need has prompted research into developing a more suitable model for studying human disease in monkeys.

Researchers at OHSU were able to insert DNA material into the monkey eggs by attaching foreign genes to the outside of monkey sperm. The scientists inserted DNA from jellyfish that encodes a gene for a glowing green protein. The DNA was then inserted into the egg using an innovative procedure adapted from infertility clinics called intracytoplasmic sperm injection or ICSI. Within two days, almost half of the monkey embryos displayed a green glow.

Seven of these genetically modified embryos were then transferred to recipient rhesus monkey females. This resulted in George, a normal male monkey. Although integration of the foreign gene into George's genetic material has not been detected yet, his birth proves that TransgenICSI is a viable method to ultimately produce genetically modified models for human disease.

A study earlier this year by a group at the University of Hawaii, led by Ryuzo Yanagimachi, Ph.D., involves the production of transgenic mice. Using the same procedure, researchers in Hawaii showed only a small percentage of animals displayed characteristics of introduced DNA later in life. This information suggests that the odds of producing transgenic monkeys as disease models will improve as protocols are refined.

Another finding of this research is that foreign DNA bound to the surface of a sperm can be transmitted during ICSI. Although this has not yet been proved to be a clinical risk, this indicates that further steps may be necessary to improve the safety of this infertility therapy.

Recently, experimental gene therapy trials in humans resulted in the tragic death of an Arizona man at the University of Pennsylvania. Schatten points to this tragedy in explaining the importance of this work. "This tragedy underscores the urgency of obtaining non-human primate models before testing begins on some desperately ill patients," said Schatten. "While gene therapy promises cures for devastating diseases, the protocols for using it and even its safety are not yet perfected. Non-human primate models are the best way to learn the benefits and risks of gene therapy."


Story Source:

The above story is based on materials provided by Oregon Health Sciences University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health Sciences University. "Oregon Health Sciences University Researchers Take Steps To Genetically Modify Monkeys For The Research Of Human Disease." ScienceDaily. ScienceDaily, 24 December 1999. <www.sciencedaily.com/releases/1999/12/991224091014.htm>.
Oregon Health Sciences University. (1999, December 24). Oregon Health Sciences University Researchers Take Steps To Genetically Modify Monkeys For The Research Of Human Disease. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/1999/12/991224091014.htm
Oregon Health Sciences University. "Oregon Health Sciences University Researchers Take Steps To Genetically Modify Monkeys For The Research Of Human Disease." ScienceDaily. www.sciencedaily.com/releases/1999/12/991224091014.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins