Featured Research

from universities, journals, and other organizations

UC Irvine Researchers Discover Molecular Interaction That Gives New Insight On How Cells Communicate

Date:
February 18, 2000
Source:
University Of California, Irvine
Summary:
UC Irvine researchers have discovered a new molecular interaction involved in embryo development that is providing fundamental information on how cells communicate during the important early stages of development.

Study, reported in Nature, offers new information on how genes act during key stages of embryo development

Related Articles


Irvine, Calif., Feb. 16, 2000 — UC Irvine researchers have discovered a new molecular interaction involved in embryo development that is providing fundamental information on how cells communicate during the important early stages of development.

Working with scientists at the National Institute for Basic Biology in Okazaki, Japan, the researchers identified a novel interaction among molecules that regulate the development of the head, back and central nervous system. Their discovery shows for the first time the linking of molecules from two key growth-regulating genes and potentially may lead to a better understanding of cellular abnormalities that can lead to colon and skin cancers.

Their findings appear in the Feb. 17 issue of Nature.

"This gives us new insight on how molecules act during the crucial early stages of development," said Ken W.Y. Cho, professor of developmental and cell biology at UCI who, along with Hiroshi Shibuya of the National Institute of Basic Biology, is a lead researcher in this study.

Researchers observed the signaling pathways of two genes-named Wnt and TGF--during the formation of frog embryos. During development, these pathways give the specific information that determines the role each cell will play. These signals travel through a series of intermediate molecules, called relay molecules, to the nucleus of a cell, where gene regulation occurs.

The UCI researchers have found that two relay molecules from the Wnt signaling pathway-named Lef and b-catenin-and one molecule from a member of the TGF-b signaling pathway-named Smad4-interact both physically and functionally. This means that the initial signals from the two gene pathways travel through these intermediate molecules for delivery to the cell nucleus.

"While it is already known that these two signaling pathways cooperate to regulate cellular events, this is the first time that their relay molecules have been shown to physically interact together instead of acting separately," Cho said.

Cho's main research interest lies in understanding the molecular activity that governs the formation of Spemann's Organizer, a region of the embryo that determines that the head, backbone, nervous system and muscles will develop in the right places. The interaction among the Lef, b-catenin and Smad4 molecules affects the formation of Spemann's Organizer. In addition, these molecules also determine other cell activity in both developing and adult organisms.

Aberrations in the normal function of these molecules have been linked to some types of cancers, such as skin and colon cancers, although the exact mechanism that leads to cancer is still not well understood. This new information adds to the researchers' understanding of how these molecules function normally, which improves the potential for someday better understanding how cancers arise. In addition to Cho and Shibuya, authors of the study are Minako K. Hashimoto, Souichi Ogata and Micheline N. Laurent of UCI's Department of Developmental and Cell Biology and Michiru Nishita and Naoto Ueno of the Department of Developmental Biology at the National Institute for Basic Biology. The study was funded by the National Institutes of Health and the Pew Scholars Program.


Story Source:

The above story is based on materials provided by University Of California, Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, Irvine. "UC Irvine Researchers Discover Molecular Interaction That Gives New Insight On How Cells Communicate." ScienceDaily. ScienceDaily, 18 February 2000. <www.sciencedaily.com/releases/2000/02/000218060856.htm>.
University Of California, Irvine. (2000, February 18). UC Irvine Researchers Discover Molecular Interaction That Gives New Insight On How Cells Communicate. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2000/02/000218060856.htm
University Of California, Irvine. "UC Irvine Researchers Discover Molecular Interaction That Gives New Insight On How Cells Communicate." ScienceDaily. www.sciencedaily.com/releases/2000/02/000218060856.htm (accessed October 31, 2014).

Share This



More Plants & Animals News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Watch Baby Goose Survive A 400-Foot Cliff Dive

Watch Baby Goose Survive A 400-Foot Cliff Dive

Buzz60 (Oct. 31, 2014) For its nature series Life Story, the BBC profiled the barnacle goose, whose chicks must make a daredevil 400-foot cliff dive from their nests to find food. Jen Markham has the astonishing video. Video provided by Buzz60
Powered by NewsLook.com
World's Salamanders At Risk From Flesh-Eating Fungus

World's Salamanders At Risk From Flesh-Eating Fungus

Newsy (Oct. 31, 2014) The import of salamanders around the globe is thought to be contributing to the spread of a deadly fungus. Video provided by Newsy
Powered by NewsLook.com
Alcoholic Drinks In The E.U. Could Get Calorie Labels

Alcoholic Drinks In The E.U. Could Get Calorie Labels

Newsy (Oct. 31, 2014) A health group in the United Kingdom has called for mandatory calorie labels on alcoholic beverages in the European Union. Video provided by Newsy
Powered by NewsLook.com
Malaria Threat in Liberia as Fight Against Ebola Rages

Malaria Threat in Liberia as Fight Against Ebola Rages

AFP (Oct. 31, 2014) Focus on treating the Ebola epidemic in Liberia means that treatment for malaria, itself a killer, is hard to come by. MSF are now undertaking the mass distribution of antimalarials in Monrovia. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins