Featured Research

from universities, journals, and other organizations

Yale Scientists Give The Golgi Apparatus Its Own Identity, Paving The Way For More Targeted Cancer Research

Date:
November 22, 2000
Source:
Yale University
Summary:
Researchers at Yale have discovered that, contrary to previous beliefs, the Golgi apparatus is an organelle that exists independently of the larger endoplasmic reticulum and is a crucial component of cell division. Published in a recent issue of Nature, the discovery gives researchers a better understanding of the cell division process and of the processes present in the uncontrolled cell division that marks cancer.

Researchers at Yale have discovered that, contrary to previous beliefs, the Golgi apparatus is an organelle that exists independently of the larger endoplasmic reticulum and is a crucial component of cell division.

Related Articles


Published in a recent issue of Nature, the discovery gives researchers a better understanding of the cell division process and of the processes present in the uncontrolled cell division that marks cancer.

In normal cell division, a mother cell divides into two daughters and the division is regulated until it stops. In a skin melanoma, for example, the cell division inexplicably starts up again and continues unregulated. This study could help cancer researchers understand why the regulation stops.

"Researchers once thought that the Golgi apparatus was no more than an outgrowth of an organelle called the endoplasmic reticulum," said Graham Warren, professor of cell biology at Yale and a leading expert in the field. "We’ve shown that it is an organelle within a cell that has its own autonomy and so must grow and divide to keep pace with the growth and division of the cell it inhabits."

The Golgi apparatus sorts and modifies cell products such as hormones, growth factors and digestive enzymes, and sends them to their final destinations within the cell. For example, the Golgi decides whether a given protein will leave the cell or be delivered to the cell surface or another destination. As with all other cellular organelles, the Golgi has to grow and divide and has to be inherited.

The Golgi apparatus is normally thought of as a stack of membrane compartments through which the secretory proteins pass, but Warren and colleagues have been able to show that the Golgi has an existence even when these membranes are removed from the apparatus.

"We found that there are proteins, which we term matrix proteins, that form a scaffold to organize the membranes," said Warren. "We think this scaffold might be the Golgi apparatus proper, responsible for its growth, division and partitioning between the two daughter cells."

In past research, Warren and his team have shown that the regrowth of a mother Golgi in the newly formed daughter cells requires a number of matrix proteins that are involved in putting the new Golgi complex together.

The significance of this new finding, Warren said, is at the basic cell biological level. "People have tended to think of organelles such as the Golgi in terms of the membranes, in part because this is the structure you see by electron microscopy," said Warren. "You don't see the matrix proteins. What we have done is to focus attention on these underlying structures, which might actually be more relevant to people interested in studying the biogenesis of these organelles."

Warren said his research brings together a broad spectrum of scientific disciplines, including traditional cell biology, biochemistry, molecular biology and structural biology.

"Now that we know that the Golgi is an independent organelle that has its own identity, we can start looking at it from a basic cell biology perspective that has medical implications for diseases like cancer, " said Warren.

Warren’s research team included Joachim Seemann and Marc Pypaert at Yale and Eija Jokitalo from the Institute of Biotechnology in Helsinki, Finland.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Yale Scientists Give The Golgi Apparatus Its Own Identity, Paving The Way For More Targeted Cancer Research." ScienceDaily. ScienceDaily, 22 November 2000. <www.sciencedaily.com/releases/2000/11/001120074801.htm>.
Yale University. (2000, November 22). Yale Scientists Give The Golgi Apparatus Its Own Identity, Paving The Way For More Targeted Cancer Research. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2000/11/001120074801.htm
Yale University. "Yale Scientists Give The Golgi Apparatus Its Own Identity, Paving The Way For More Targeted Cancer Research." ScienceDaily. www.sciencedaily.com/releases/2000/11/001120074801.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins