St. Louis, Jan. 12, 2001 —- As bacteria become resistant to current antibiotics, scientists are searching for the root causes of infection in order to develop more effective treatments. Researchers at Washington University School of Medicine in St. Louis have come one step closer to understanding how bacteria such as Streptococcus and Staphylococcus operate: These pathogens introduce their toxins by punching holes in the host-cell membrane. The cover of the Jan. 12 issue of Cell features the research. Scientists have made great strides in understanding how Gram-negative bacteria, such as Salmonella and E. coli, infiltrate host cells and establish infection. However, a second class of bacteria called Gram-positive causes human diseases such as strep throat, necrotizing faciitis, toxic shock syndrome and rheumatic fever. "Gram-positive organisms are responsible for five of the top six bacterial infections that are now resistant to multiple antibiotics available today," says study leader Michael G. Caparon, Ph.D., associate professor of molecular microbiology.
The above story is based on materials provided by Washington University School Of Medicine. Note: Materials may be edited for content and length.
Cite This Page: