Featured Research

from universities, journals, and other organizations

Keeping A Tight Rein On Cell Division

Date:
April 23, 2001
Source:
Rockefeller University Press
Summary:
Normal cells need two signals in order to divide: a growth factor protein, and an indication that the cells are attached to the “correct” surface. Researchers have now discovered how these two signals are integrated.

Normal cells need two signals in order to divide: a growth factor protein, and an indication that the cells are attached to the “correct” surface. Researchers have now discovered how these two signals are integrated. Loss of control over the attachment signal may allow cancer cells to grow even when they are not in the correct part of the body.

Related Articles


Andrew Aplin (University of North Carolina at Chapel Hill) and colleagues report in the April 16 issue of The Journal of Cell Biology that growth factors turn on a set of proteins called extracellular-regulated kinases (ERKs). To do their job, active ERKs have to be in the nucleus, the region of the cell that stores DNA. But in cells that are not attached to a surface, active ERKs stay in the cytoplasm, the region outside of the nucleus. Only when cells stick down to an appropriate surface are the ERKs further modified so that they can enter the nucleus and prompt the cell to multiply.

Many cancer cells can grow without contacting anything, or when they are contacting an unusual surface in a different part of the body that they do not usually encounter. The cancer cells may gain this ability by modifying the control of ERK proteins so that the ERK proteins automatically enter the nucleus.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "Keeping A Tight Rein On Cell Division." ScienceDaily. ScienceDaily, 23 April 2001. <www.sciencedaily.com/releases/2001/04/010417074715.htm>.
Rockefeller University Press. (2001, April 23). Keeping A Tight Rein On Cell Division. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2001/04/010417074715.htm
Rockefeller University Press. "Keeping A Tight Rein On Cell Division." ScienceDaily. www.sciencedaily.com/releases/2001/04/010417074715.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins