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Mouse Gene Knockout Illuminates How Light Resets Clock

Date:
December 16, 2002
Source:
NIH/National Institute Of Mental Health
Summary:
A key role in synchronizing daily rhythms to the day/night cycle has been traced to a light-sensitive protein in the eye, by knocking out the gene that codes for it. Mice lacking a gene for the photopigment melanopsin show a dramatic deficiency in their ability to regulate their circadian rhythms by light.

A key role in synchronizing daily rhythms to the day/night cycle has been traced to a light-sensitive protein in the eye, by knocking out the gene that codes for it. Mice lacking a gene for the photopigment melanopsin show a dramatic deficiency in their ability to regulate their circadian rhythms by light. The discovery, by National Institute of Mental Health (NIMH) grantees, helps unravel the heretofore elusive mechanisms by which day/night cycles regulate such rhythms in mammals. NIMH grantees Ignacio Provencio, Ph.D., Uniformed Services University of the Health Sciences (USUHS), and Steve Kay, Ph.D., The Scripps Research Institute, and colleagues report on their findings in the December 13 Science.*


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The above story is based on materials provided by NIH/National Institute Of Mental Health. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Mental Health. "Mouse Gene Knockout Illuminates How Light Resets Clock." ScienceDaily. ScienceDaily, 16 December 2002. <www.sciencedaily.com/releases/2002/12/021216071528.htm>.
NIH/National Institute Of Mental Health. (2002, December 16). Mouse Gene Knockout Illuminates How Light Resets Clock. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2002/12/021216071528.htm
NIH/National Institute Of Mental Health. "Mouse Gene Knockout Illuminates How Light Resets Clock." ScienceDaily. www.sciencedaily.com/releases/2002/12/021216071528.htm (accessed April 20, 2014).

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