Featured Research

from universities, journals, and other organizations

Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies

Date:
June 4, 2003
Source:
Thomas Jefferson University
Summary:
Researchers at the Biotechnology Foundation at Jefferson Medical College have genetically engineered tobacco plants to produce human proteins – antibodies – against rabies.

Researchers at the Biotechnology Foundation at Jefferson Medical College have genetically engineered tobacco plants to produce human proteins – antibodies – against rabies. Scientists, led by Hilary Koprowski, M.D., professor of microbiology and immunology and director of the Biotechnology Foundation Laboratories and the Center for Neurovirology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and Kisung Ko, Ph.D., research associate at the Biotechnology Foundation at Jefferson Medical College, have inserted DNA coding for an antibody against the rabies virus into tobacco plants. The plants, in turn, become factories churning out antibody.

Related Articles


The report appears online this week in the Proceedings of the National Academy of Sciences.

According to Dr. Koprowski, who created the currently used vaccine against rabies, there is a worldwide shortage of antibodies against rabies. They are expensive to get from humans and antibodies derived from horse blood carry unwanted side effects.

The researchers first showed that antibody could neutralize rabies virus and prevent infection in mice. Using plant antibody, Chuck Rupprecht, D.V.M., chief of rabies at the Centers for Disease Control and Prevention in Atlanta, prevented rabies in hamsters inoculated with a lethal dose of "street" virus.

"The antibody produced in tobacco is as good as the antibody produced in animal cells," says Dr. Koprowski, noting that tobacco-derived human rabies antibody should be safer and less expensive to produce.

Rabies, which is fatal and incurable, is usually acquired through the bite of an infected animal. If treatment with antibody and vaccine is given as soon as possible after exposure to the virus, it may prevent rabies.

Dr. Koprowski points out that an antibody would be used in cases of severe animal bites. "A vaccine might be too late to develop antibodies," he says. "The recommendation is to first inject the antibody serum, then give the vaccine," which in turn elicits the production of antibodies for long-term protection.

Dr. Koprowski stresses the need for a commercially available antibody against rabies. He says that up to about 50,000 cases of human rabies occur annually in Asia (40 percent in children) and 7.5 million people receive the treatment after exposure.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies." ScienceDaily. ScienceDaily, 4 June 2003. <www.sciencedaily.com/releases/2003/06/030604083815.htm>.
Thomas Jefferson University. (2003, June 4). Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2003/06/030604083815.htm
Thomas Jefferson University. "Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies." ScienceDaily. www.sciencedaily.com/releases/2003/06/030604083815.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com
Rover Finds More Clues About Possible Life On Mars

Rover Finds More Clues About Possible Life On Mars

Newsy (Dec. 17, 2014) NASA's Curiosity rover detected methane on Mars and organic compounds on the surface, but it doesn't quite prove there was life ... yet. Video provided by Newsy
Powered by NewsLook.com
Ivory Trade Boom Swamps Law Efforts

Ivory Trade Boom Swamps Law Efforts

Reuters - Business Video Online (Dec. 17, 2014) Demand for ivory has claimed the lives of tens of thousands of African elephants and now a conservation report says the illegal trade is overwhelming efforts to enforce the law. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins