Featured Research

from universities, journals, and other organizations

Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies

Date:
June 4, 2003
Source:
Thomas Jefferson University
Summary:
Researchers at the Biotechnology Foundation at Jefferson Medical College have genetically engineered tobacco plants to produce human proteins – antibodies – against rabies.

Researchers at the Biotechnology Foundation at Jefferson Medical College have genetically engineered tobacco plants to produce human proteins – antibodies – against rabies. Scientists, led by Hilary Koprowski, M.D., professor of microbiology and immunology and director of the Biotechnology Foundation Laboratories and the Center for Neurovirology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and Kisung Ko, Ph.D., research associate at the Biotechnology Foundation at Jefferson Medical College, have inserted DNA coding for an antibody against the rabies virus into tobacco plants. The plants, in turn, become factories churning out antibody.

The report appears online this week in the Proceedings of the National Academy of Sciences.

According to Dr. Koprowski, who created the currently used vaccine against rabies, there is a worldwide shortage of antibodies against rabies. They are expensive to get from humans and antibodies derived from horse blood carry unwanted side effects.

The researchers first showed that antibody could neutralize rabies virus and prevent infection in mice. Using plant antibody, Chuck Rupprecht, D.V.M., chief of rabies at the Centers for Disease Control and Prevention in Atlanta, prevented rabies in hamsters inoculated with a lethal dose of "street" virus.

"The antibody produced in tobacco is as good as the antibody produced in animal cells," says Dr. Koprowski, noting that tobacco-derived human rabies antibody should be safer and less expensive to produce.

Rabies, which is fatal and incurable, is usually acquired through the bite of an infected animal. If treatment with antibody and vaccine is given as soon as possible after exposure to the virus, it may prevent rabies.

Dr. Koprowski points out that an antibody would be used in cases of severe animal bites. "A vaccine might be too late to develop antibodies," he says. "The recommendation is to first inject the antibody serum, then give the vaccine," which in turn elicits the production of antibodies for long-term protection.

Dr. Koprowski stresses the need for a commercially available antibody against rabies. He says that up to about 50,000 cases of human rabies occur annually in Asia (40 percent in children) and 7.5 million people receive the treatment after exposure.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies." ScienceDaily. ScienceDaily, 4 June 2003. <www.sciencedaily.com/releases/2003/06/030604083815.htm>.
Thomas Jefferson University. (2003, June 4). Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2003/06/030604083815.htm
Thomas Jefferson University. "Jefferson Scientists Create Tobacco Plant To Produce Antibodies Against Rabies." ScienceDaily. www.sciencedaily.com/releases/2003/06/030604083815.htm (accessed April 17, 2014).

Share This



More Plants & Animals News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Raw: Three Rare White Tiger Cubs Debut at Zoo

Raw: Three Rare White Tiger Cubs Debut at Zoo

AP (Apr. 16, 2014) The Buenos Aires Zoo debuted a trio of rare white Bengal tiger cubs on Wednesday. (April 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins