Featured Research

from universities, journals, and other organizations

Ohio State Creates First Gene Chip For Horse

Date:
December 17, 2003
Source:
Ohio State University
Summary:
Researchers at Ohio State University have created the first DNA gene chip that contains thousands of the genes for a horse and one of the first gene chips for a domestic animal.

COLUMBUS, Ohio -- Researchers at Ohio State University have created the first DNA gene chip that contains thousands of the genes for a horse and one of the first gene chips for a domestic animal.

The new chip houses more than 3,200 expressed horse genes on a sliver of glass about the size of a postage stamp. When the researchers began developing this chip two years ago, only 200 horse genes were known.

This new chip will allow researchers to scan an individual horses genes at once to see which ones are active in a certain situation. For example, drug companies might use a gene chip to predict how a particular drug will affect an animal.

Since their invention nearly a decade ago, gene chips have revolutionized some basic approaches to research. Having a representative gene chip for a large animal could lead to better accuracy in studying human disease. Commercial gene chips already exist for humans, mice, rats, rice plants and a number of microorganisms.

"Although we rely on animal models to study human diseases, we really aren't sure what some of the genetic differences are between those animal models and humans," said Alicia Bertone, the professor of veterinary clinical sciences who led Ohio State's efforts in developing the equine gene chip.

"The genetic differences between humans and most animals are small in most cases, more than 90 percent of our DNA is similar," Bertone said. Knowing which genes are similar can be a boon to researchers who use animal models to learn about human diseases.

"Gene chips can help uncover these key differences, giving us critical information before we launch into an experiment," Bertone said. "The scientific community has invested a lot of money in animal models that don't truly represent the human situation, so having this kind of information is extremely beneficial."

Bertone developed the chip with the help of Weisong Gu, a postdoctoral researcher in veterinary clinical sciences at Ohio State. Gu created a computer program that helped he and Bertone discover and describe 3,088 horse genes. They added these genes to the 200 already-known genes to create the chip. In order to define the genes, the researchers compared sequences of horse DNA to already-known human genes. Bertone said there are likely thousands of more genes yet to be identified for the horse.

Data derived from the equine gene chip could give researchers insight into gene expression for specific equine and human diseases and conditions. For example, gene chips let researchers see how thousands of genes respond to an illness. This information can be used clinically to study disease in horses and in translational research from horse to human.

"The closer we can demonstrate that an animal model really mimics a human disease, the better off we are," said Bertone, adding that horses are often used as models for orthopedic diseases, such as osteoarthritis and osteochondrosis a disease that inhibits bone growth. The equine gene chip can also be used to identify horse diseases such as equine protozoal myelitis (EPM), a debilitating neurological disease. Also, testing a drug or other therapy is typically done in large animals, such as horses, dogs and cats, before being tested on humans.

"More accurate animal models mean we'll spend less money on and use fewer animals for finding cures," Bertone said. "Billions of dollars are invested in developing drugs that work really well in mice but fail in larger animal models and humans."

The new equine chip includes genes that regulate cell death, the cell cycle, cell signaling and development. The cost of the chip is around $350 to $450.

This work was supported in part by Affymetrix, Inc., the manufacturer of a variety of gene chips.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Ohio State Creates First Gene Chip For Horse." ScienceDaily. ScienceDaily, 17 December 2003. <www.sciencedaily.com/releases/2003/12/031216075043.htm>.
Ohio State University. (2003, December 17). Ohio State Creates First Gene Chip For Horse. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2003/12/031216075043.htm
Ohio State University. "Ohio State Creates First Gene Chip For Horse." ScienceDaily. www.sciencedaily.com/releases/2003/12/031216075043.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins