Featured Research

from universities, journals, and other organizations

DNA Vaccine Protects Against Anthrax

Date:
March 10, 2004
Source:
American Society For Microbiology
Summary:
A new DNA vaccine against anthrax provides complete protection against aerosolized spores in rabbits, say researchers from the Ohio University and the Naval Medical Research Center.

BALTIMORE, MD – March 9, 2004 -- A new DNA vaccine against anthrax provides complete protection against aerosolized spores in rabbits, say researchers from the Ohio University and the Naval Medical Research Center. They report their results today at the American Society for Microbiology's Biodefense Research Meeting.

Related Articles


"The naked DNA approach is vaccination at its simplest. The gene encoding the vaccine is introduced into the host and expressed in vivo where it stimulates a protective immune response," says Matthew Bell, of the Ohio State University, one of the researchers on the study.

Having previously shown the effectiveness of a DNA vaccine in mice, Bell and his colleagues tested the vaccine on a higher form of mammal: rabbits. The animals were given a vaccine made of DNA that coded for either the lethal factor (LF) or the protective antigen (PA) component of the anthrax toxin in order to stimulate the immune system to produce antibodies against those compounds. The researchers tested the ability of the vaccine to both stimulate antibody production and protect against lethal infection. While the LF-based DNA vaccine appeared to stimulate higher levels of antibodies, only 56% of the rabbits survived an aerosolized spore challenge. In contrast all of the rabbits given the PA-based DNA vaccine survived.

"Although LF stimulates higher antibody titers than PA, immunization with PA induces antibodies that are more capable of neutralizing toxin and conferring protection," says Bell.

###

The American Society for Microbiology (ASM) is the largest single life science society, composed of over 42,000 scientists, teachers, physicians, and health professionals. Its mission is to promote research and training in the microbiological sciences and to assist communication between scientists, policymakers, and the public to improve health, economic well being, and the environment.

Further information on the ASM Biodefense Research Meeting can be found online at http://www.asmbiodefense.org.


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "DNA Vaccine Protects Against Anthrax." ScienceDaily. ScienceDaily, 10 March 2004. <www.sciencedaily.com/releases/2004/03/040310080118.htm>.
American Society For Microbiology. (2004, March 10). DNA Vaccine Protects Against Anthrax. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2004/03/040310080118.htm
American Society For Microbiology. "DNA Vaccine Protects Against Anthrax." ScienceDaily. www.sciencedaily.com/releases/2004/03/040310080118.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins