Featured Research

from universities, journals, and other organizations

UCSB Researchers Advance Understanding Of Urinary Tract Infections

Date:
November 22, 2004
Source:
University Of California - Santa Barbara
Summary:
Scientists at the University of California, Santa Barbara have made important strides in understanding E. coli at the molecular level in an effort to discover the mechanisms by which E. coli cause urinary tract infections.

Santa Barbara, Calif. –– Anyone who has ever had a urinary tract infection knows that they can be difficult to fight.

The bacterium E. coli is responsible for about 80 percent of human urinary tract infections. Scientists at the University of California, Santa Barbara have made important strides in understanding E. coli at the molecular level in an effort to discover the mechanisms by which E. coli cause urinary tract infections. The findings, the result of two years of study, are published in the November 19 issue of the journal Molecular Cell.

In this study, the scientists –– all associated with the Department of Molecular, Cellular and Developmental Biology –– focused on the mechanisms by which these bacteria, which normally live in the bowel, adhere to and colonize the urinary tract.

The scientists, Aaron D. Hernday, Bruce A. Braaten, Gina Broitman-Maduro, Patrick Engelberts, and David A. Low, studied how the expression of "pili" on the surface of the E. coli cells is controlled by environmental conditions. "Pili" are hair-like cell surface structures that play an important role in the adherence of the cells. If the cells cannot adhere and colonize, then they wash out of the urinary tract.

Certain stressful conditions can influence the genetic "switch" that causes the bacteria to be covered in pili. According to the findings this switch is either on or off. The study shows a mechanism by which a sensor called Cpx detects stressful environmental conditions and sends a signal to turn the switch off. This response may be important in allowing bacterial survival under stressful conditions.


Story Source:

The above story is based on materials provided by University Of California - Santa Barbara. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Santa Barbara. "UCSB Researchers Advance Understanding Of Urinary Tract Infections." ScienceDaily. ScienceDaily, 22 November 2004. <www.sciencedaily.com/releases/2004/11/041121215642.htm>.
University Of California - Santa Barbara. (2004, November 22). UCSB Researchers Advance Understanding Of Urinary Tract Infections. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2004/11/041121215642.htm
University Of California - Santa Barbara. "UCSB Researchers Advance Understanding Of Urinary Tract Infections." ScienceDaily. www.sciencedaily.com/releases/2004/11/041121215642.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins