Featured Research

from universities, journals, and other organizations

Restless Legs Syndrome Has Complex Genetic Involvement

Date:
April 21, 2005
Source:
Journal Of The American Medical Association
Summary:
A new study confirmed that a gene associated with restless legs syndrome (RLS) susceptibility is located on chromosome 12q and and also suggests that at least one other gene may be involved in restless leg syndrome, according to an article in the April issue of the Archives of Neurology, one of the JAMA/Archives journals.

CHICAGO — A new study confirmed that a gene associated with restless legs syndrome (RLS) susceptibility is located on chromosome 12q and and also suggests that at least one other gene may be involved in restless leg syndrome, according to an article in the April issue of the Archives of Neurology, one of the JAMA/Archives journals.

Related Articles


Restless legs syndrome is one of the leading causes of insomnia, affecting more than five to 10 percent of the white population, according to background information in the article. Genetic contributions to restless legs syndrome have been consistently supported by population, family and twin studies. To identify genetic risk factors, the current study used information from French Canadian families, where, according to the researchers, prevalence of restless legs syndrome is higher than in other populations.

Alex Desautels, Ph.D., of the University of Montreal, and colleagues examined the DNA of 19 multigenerational French Canadian families with four to nine individuals who were affected (or possibly affected) by restless legs syndrome. The researchers used statistical analysis of the genetic information to determine whether restless legs syndrome in each family was linked with markers on the same location on chromosome 12q that had previously been associated with restless legs syndrome.

Two-hundred-seventy-six individuals were included in the study, including 146 affected individuals, 39 possibly affected individuals and 91 unaffected family members. The researchers confirmed that the syndrome was consistent with linkage to chromosome 12q within five families. Linkage to that location was formally excluded for six other families. The researchers compared clinical features of the syndrome in affected individuals from the different families to see if those differences correlated with the differences in linkage. They found that one feature, periodic leg movements during sleep, was significantly greater for affected individuals from the linked families than for affected individuals from the unlinked families.

"These results further support the involvement of an RLS-susceptibility locus [gene location] on chromosome 12q in the FC [French Canadian] population and also provide evidence that there must be other loci involved in this common sleep disorder," the authors conclude. "Furthermore, our findings illustrate that extensive characterization of subclinical differences represents a major tool in the identification of susceptibility loci for complex diseases … Although the background of RLS is most likely complex, this finding may offer a new starting point for further dissecting the genetic cause of RLS."

(Arch Neurol. 2005;62:591-596. Available post-embargo at archneurol.com)

Editor's Note: This study was supported in part by research grants from the Canadian Institutes of Health Research (CIHR), Ottawa and from the National Institutes of Health, Bethesda, Md. Dr. Desautels is a recipient of the CIHR studentship.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Restless Legs Syndrome Has Complex Genetic Involvement." ScienceDaily. ScienceDaily, 21 April 2005. <www.sciencedaily.com/releases/2005/04/050420091807.htm>.
Journal Of The American Medical Association. (2005, April 21). Restless Legs Syndrome Has Complex Genetic Involvement. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2005/04/050420091807.htm
Journal Of The American Medical Association. "Restless Legs Syndrome Has Complex Genetic Involvement." ScienceDaily. www.sciencedaily.com/releases/2005/04/050420091807.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins