Featured Research

from universities, journals, and other organizations

Restless Legs Syndrome Has Complex Genetic Involvement

Date:
April 21, 2005
Source:
Journal Of The American Medical Association
Summary:
A new study confirmed that a gene associated with restless legs syndrome (RLS) susceptibility is located on chromosome 12q and and also suggests that at least one other gene may be involved in restless leg syndrome, according to an article in the April issue of the Archives of Neurology, one of the JAMA/Archives journals.

CHICAGO — A new study confirmed that a gene associated with restless legs syndrome (RLS) susceptibility is located on chromosome 12q and and also suggests that at least one other gene may be involved in restless leg syndrome, according to an article in the April issue of the Archives of Neurology, one of the JAMA/Archives journals.

Restless legs syndrome is one of the leading causes of insomnia, affecting more than five to 10 percent of the white population, according to background information in the article. Genetic contributions to restless legs syndrome have been consistently supported by population, family and twin studies. To identify genetic risk factors, the current study used information from French Canadian families, where, according to the researchers, prevalence of restless legs syndrome is higher than in other populations.

Alex Desautels, Ph.D., of the University of Montreal, and colleagues examined the DNA of 19 multigenerational French Canadian families with four to nine individuals who were affected (or possibly affected) by restless legs syndrome. The researchers used statistical analysis of the genetic information to determine whether restless legs syndrome in each family was linked with markers on the same location on chromosome 12q that had previously been associated with restless legs syndrome.

Two-hundred-seventy-six individuals were included in the study, including 146 affected individuals, 39 possibly affected individuals and 91 unaffected family members. The researchers confirmed that the syndrome was consistent with linkage to chromosome 12q within five families. Linkage to that location was formally excluded for six other families. The researchers compared clinical features of the syndrome in affected individuals from the different families to see if those differences correlated with the differences in linkage. They found that one feature, periodic leg movements during sleep, was significantly greater for affected individuals from the linked families than for affected individuals from the unlinked families.

"These results further support the involvement of an RLS-susceptibility locus [gene location] on chromosome 12q in the FC [French Canadian] population and also provide evidence that there must be other loci involved in this common sleep disorder," the authors conclude. "Furthermore, our findings illustrate that extensive characterization of subclinical differences represents a major tool in the identification of susceptibility loci for complex diseases … Although the background of RLS is most likely complex, this finding may offer a new starting point for further dissecting the genetic cause of RLS."

(Arch Neurol. 2005;62:591-596. Available post-embargo at archneurol.com)

Editor's Note: This study was supported in part by research grants from the Canadian Institutes of Health Research (CIHR), Ottawa and from the National Institutes of Health, Bethesda, Md. Dr. Desautels is a recipient of the CIHR studentship.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Restless Legs Syndrome Has Complex Genetic Involvement." ScienceDaily. ScienceDaily, 21 April 2005. <www.sciencedaily.com/releases/2005/04/050420091807.htm>.
Journal Of The American Medical Association. (2005, April 21). Restless Legs Syndrome Has Complex Genetic Involvement. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2005/04/050420091807.htm
Journal Of The American Medical Association. "Restless Legs Syndrome Has Complex Genetic Involvement." ScienceDaily. www.sciencedaily.com/releases/2005/04/050420091807.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins