Featured Research

from universities, journals, and other organizations

Small Worm Yields Big Clue On Muscle Receptor Action

Date:
July 27, 2005
Source:
University of Illinois at Chicago
Summary:
Biological researchers report the identity of a previously elusive subunit of a neurotransmitter in C. elegans. The finding may have applicability to research on the human nervous system.

Researchers at the University of Illinois at Chicago have identified an elusive subunit of a neurotransmitter receptor found in both humans and the much-studied laboratory nematode C. elegans which may open new pathways of research on muscle function.

The neurotransmitter acetylcholine binds to two different nicotinic receptors at the nematode's neuromuscular junctions, causing them to contract. Previously, researchers knew the subunit composition only of the levamisole-sensitive acetylcholine receptors. In the second, levamisole-insensitive acetylcholine receptors, a subunit called acetylcholine receptor 16, or ACR-16, has now been identified as necessary for this receptor's contribution to muscle contraction.

Janet Richmond, assistant professor of biological sciences at UIC, along with graduate students Denis Touroutine and Anna Burdina, reported the findings in the July 22 issue of the Journal of Biological Chemistry. The research also drew on bioinformatic data provided by David Miller, associate professor of cell and developmental biology at Vanderbilt University, and work by his graduate students Rebecca Fox and Stephen Von Stetina.

Richmond has developed a preparation for cutting open the microscopic nematode to record muscle responses when acetylcholine is applied. Using this preparation, Richmond was still getting muscle contraction when acetylcholine was applied to worms lacking any of five receptor subunits known to be sensitive to levamisole, a chemical that poisons nematodes. Two additional receptor subunits -- ACR-16 and ACR-8 -- identified using Vanderbilt's data, were found to be likely candidates for the remaining acetylcholine response. ACR-16 was singled out as the key subunit.

"We've shown the ACR-16-containing receptor is present in muscle and contributes hugely to the synaptic current," said Richmond.

"Now we can tag this receptor, see if it's localized at the synapse and start to mutagenize animals to figure out what makes that receptor stay or make it to the synapse," she added.

Richmond said the finding might have direct relevance to humans because the ACR-16 receptor is very similar to the alpha-7 nicotinic receptor in the human brain.

###

The research was funded by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Small Worm Yields Big Clue On Muscle Receptor Action." ScienceDaily. ScienceDaily, 27 July 2005. <www.sciencedaily.com/releases/2005/07/050727060209.htm>.
University of Illinois at Chicago. (2005, July 27). Small Worm Yields Big Clue On Muscle Receptor Action. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2005/07/050727060209.htm
University of Illinois at Chicago. "Small Worm Yields Big Clue On Muscle Receptor Action." ScienceDaily. www.sciencedaily.com/releases/2005/07/050727060209.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins