Featured Research

from universities, journals, and other organizations

Simple Sea Sponge Helps Scientists Understand Tissue Rejection

Date:
August 19, 2005
Source:
Marine Biological Laboratory
Summary:
Xavier Fernŕndez-Busquets, an MBL researcher visiting from the University of Barcelona, has found the perfect ally in this quest Understanding why some transplant patients reject their new organs - the red beard sea sponge.

The red beard sponge.
Credit: Image courtesy of Marine Biological Laboratory

Understanding why some transplant patients reject their neworgans requires a working knowledge of how cells recognize and acceptor reject each other. Xavier Fernŕndez-Busquets, an MBL researchervisiting from the University of Barcelona, has found the perfect allyin this quest: the red beard sea sponge, an Atlantic species that growsabundantly from just north of Cape Cod down to Florida.

Related Articles


The redbeard sponge (Microciona prolifera) has a cell-to-cell recognitionsystem that, on a basic level, is similar to that of humans but muchsimpler. It’s also a good organism for laboratory research, since itscells and cell adhesion molecules can be isolated with simple, fast,and non-disruptive methods and studied, and because its fingerlikestructures make grafting experiments relatively straightforward.

Inexperiments carried out on these sponges this summer, Dr.Fernŕndez-Busquets and his colleagues are studying the cells andmolecules believed to be involved in the process of tissue rejection.By grafting together pieces of different individual sponges that willreject each other—a process that approximates what sometimes happens inhuman transplants—the scientists have observed that cells known as graycells migrate to and amass at the graft site, a clear suggestion thatthey are involved in non-self tissue recognition and rejection.Researchers believe that gray cells may be a primitive form of ourimmune system’s human killer cells.

Fernŕndez-Busquets has alsobeen researching the role of the molecule called aggregation factorproteoglycan, which he has recently identified as another potentialplayer in sponge tissue rejection reactions, and which is very easy tostudy in sponges. The human version of this molecule, which isdifferent from the sponge version but similar in structure, is alsobelieved to have important functions in cell-to-cell interactions, butis hard to study.

The ultimate goal of this research is toprovide insights into the machinery behind human tissue rejection andimmune responses in hopes of someday being able to control theseprocesses and save lives.


Story Source:

The above story is based on materials provided by Marine Biological Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Marine Biological Laboratory. "Simple Sea Sponge Helps Scientists Understand Tissue Rejection." ScienceDaily. ScienceDaily, 19 August 2005. <www.sciencedaily.com/releases/2005/08/050819094409.htm>.
Marine Biological Laboratory. (2005, August 19). Simple Sea Sponge Helps Scientists Understand Tissue Rejection. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2005/08/050819094409.htm
Marine Biological Laboratory. "Simple Sea Sponge Helps Scientists Understand Tissue Rejection." ScienceDaily. www.sciencedaily.com/releases/2005/08/050819094409.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) — Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) — Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) — A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins