September 22, 2005
Howard Hughes Medical Institute
Antibiotic resistance puts humans in an escalating "arms race" with bacteria, as scientists try to develop new antibiotics faster than the bacteria can evolve new resistance strategies. Now researchers are reproducing in the lab the natural evolution of the bacterial enzymes that confer resistance, which could give drug designers a sneak peek at the next generation of resistance.
In this close-up of the metallo-beta-lactamase enzyme's active site (in red), the two essential metal ions (blue spheres) and a beta-lactam antibiotic (colored sticks) are highlighted. The activity of this enzyme has been optimized by in vitro evolution resulting from exposure to large amounts of antibiotics. Over the black background (on top), a large number of antibiotic molecules are depicted.
Credit: Image : Pablo E. Tomatis
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Howard Hughes Medical Institute. "Gaining Ground In The Race Against Antibiotic Resistance." ScienceDaily. ScienceDaily, 22 September 2005. <www.sciencedaily.com/releases/2005/09/050922021043.htm>.
Howard Hughes Medical Institute. (2005, September 22). Gaining Ground In The Race Against Antibiotic Resistance. ScienceDaily. Retrieved March 9, 2014 from www.sciencedaily.com/releases/2005/09/050922021043.htm
Howard Hughes Medical Institute. "Gaining Ground In The Race Against Antibiotic Resistance." ScienceDaily. www.sciencedaily.com/releases/2005/09/050922021043.htm (accessed March 9, 2014).