Featured Research

from universities, journals, and other organizations

Collaborative Cross To Provide Powerful Resource For Mouse Model Researchers Worldwide

September 25, 2005
DOE/Oak Ridge National Laboratory
A thousand new strains of mice being bred at Oak Ridge National Laboratory as part of an international effort will provide researchers with a powerful resource for studying human disease.

Related Articles

The project, dubbed the CollaborativeCross, has officially begun with a $1.25 million grant over five yearsfrom the Ellison Medical Foundation. When completed in about sevenyears, researchers worldwide will be able to fully exploit the geneticpower of the mouse. Each of the estimated 1,000 strains derived fromthe carefully selected original eight breeds represents a resource thatcan be used repeatedly to accumulate data.

"Ultimately, thiseffort will allow us to do a much better job of modeling humanpopulations and diseases because we will have 1,000 lines of mice thatcarry the kinds of genetic diversity representative of people," saidDabney Johnson, a genetics researcher in ORNL's Life Sciences Division.Johnson headed a team that wrote the proposal to the Ellison MedicalFoundation.

At the heart of the project is the new $14 millionLaboratory for Comparative Functional Genomics at the Department ofEnergy's ORNL. The pathogen-free 36,000-square-foot facility completedin 2004 boasts accommodations for 80,000 mice, cryogenic storage andother state-of-the-art features. It is at this designated DOE userfacility that the breeding of the eight strains taken from around theworld will be performed to initiate up to 1,500 strains of mice. Ofthose, researchers expect about 1,000 strains to be viable asinbreeding proceeds.

Without DOE's stewardship of the new mousefacility, the project would not be possible, said Johnson, who notedthat DOE is contributing not only the space within the facility butalso the technical capabilities that will allow the work to beperformed.

The project, which will occupy about half of the newORNL mouse house's capacity, is a perfect fit for ORNL, according toJohnson. "Projects like this are a big part of why the Department ofEnergy built this facility. We now have the building and the resourcesto host a project with potentially vast benefits to people around theworld," she said.

Several universities and institutions,including The Jackson Laboratory, the University of Tennessee and theUniversity of North Carolina, are participating in the effort, whichJohnson hopes continues to gain momentum over the next several months.Already, researchers around the world have expressed significantinterest and Jackson Lab has provided the parental strains of mice.

Theproject represents a significant departure from previous approaches andresearchers say is necessary to take the next step in developing acommunity resource for understanding the genetic and environmentalcomplexity of human diseases.

"For the last 30 years it has beenall right to study one gene at a time, but we realize that we've goneas far as we can with that approach," Johnson said. "So this is theonly way to accomplish what we're setting out to do now. When we'redone, we will have reduced genome sections to small enough pieces thatonly one to five genes are possible candidates to control a specifictrait."

Controlling environmental variables will play a huge rolein enabling researchers to identify and potentially diagnose and treatan assortment of chronic human conditions, including cancer, pulmonaryand cardiovascular diseases, obesity, diabetes, behavioral disordersand neurodegenerative diseases.

Another component of the projectwill be exposure biology, which ultimately attempts to explain why somepeople are more susceptible to toxins or other insults than others.Johnson also expects the Collaborative Cross to attract guestresearchers who will be provided with laboratory space to work onspecial projects that have been approved by an external review board.The four-member board consists of renowned researchers from CaseWestern Reserve University, The Jackson Laboratory, Lawrence LivermoreNational Laboratory and Battelle Memorial Institute.

Johnson alsonoted that the project will generate large amounts of data and enablepredictive modeling and simulation that will require the resourcesprovided by ORNL's supercomputer. In 2004, ORNL was selected as thesite for DOE's National Leadership Computing Facility, which with 50teraflops of sustained capacity and a capacity of 250 peak teraflopswill be the world's most powerful supercomputer for research.

ORNLis managed by UT-Battelle for the Department of Energy. Funding for themouse facility is provided by DOE's Office of Biological andEnvironmental Research within the Office of Science. The EllisonMedical Foundation supports basic biomedical research on aging relevantto understanding aging processes and age-related diseases anddisabilities.

Story Source:

The above story is based on materials provided by DOE/Oak Ridge National Laboratory. Note: Materials may be edited for content and length.

Cite This Page:

DOE/Oak Ridge National Laboratory. "Collaborative Cross To Provide Powerful Resource For Mouse Model Researchers Worldwide." ScienceDaily. ScienceDaily, 25 September 2005. <www.sciencedaily.com/releases/2005/09/050925153306.htm>.
DOE/Oak Ridge National Laboratory. (2005, September 25). Collaborative Cross To Provide Powerful Resource For Mouse Model Researchers Worldwide. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2005/09/050925153306.htm
DOE/Oak Ridge National Laboratory. "Collaborative Cross To Provide Powerful Resource For Mouse Model Researchers Worldwide." ScienceDaily. www.sciencedaily.com/releases/2005/09/050925153306.htm (accessed April 19, 2015).

Share This

More From ScienceDaily

More Plants & Animals News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:

Strange & Offbeat Stories

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins