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BookmarkScienceDaily (Mar. 7, 2006) — A study by researchers at New York University and the University of London offers additional evidence that mammals and fruit flies share a common genetic makeup that determines the function of their internal biological clocks. The study appears in the latest issue of Current Biology. The research team consisted of post-doctoral researcher Ben Collins, Esteban Mazzoni, a graduate student, and Assistant Professor Justin Blau of NYU's Department of Biology and Professor Ralf Stanewsky of the University of London.
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Drosophila fruit flies are commonly used for research on biological, or circadian, clocks because of the relative ease of finding mutants with non-24-hour rhythms and then identifying the genes underlying the altered behavior. These studies in fruit flies have allowed the identification of similar "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. However, prior to this study, biologists had concluded that the role of one protein--Cryptochrome (Cry)--was quite different between flies and mammals. In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons, or in jet lag-style experiments (in which light is manipulated to mimic the experience of traveling over multiple time zones) in the lab. In mammals, however, Cry assists in the 24-hour rhythmic expression of clock genes and has nothing to do with re-setting the clock.
The researchers sought to determine additional roles for Cry in fruit flies by testing the rhythmic expression of clock genes in flies with either a mutant version of Cry, or with Cry produced at artificially high levels. In both cases, they found that the clock had stopped -- with high levels of clock gene expression when Cry was mutated, and low levels when Cry was over-produced. These results indicated that Cry normally inhibits clock gene expression in many clock cells -- just as it does in the mammalian clock.
"In addition to finding a new function for Cryptochrome, the results reinforce that notion that fruit flies provide an excellent model for understanding the human biological clock that drives sleep/wake cycles and many other processes that contribute to our overall health," said Blau.
The research was supported by a grant from the National Institutes of Health.
