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Studies Evaluate Health Effects Of Dental Amalgam In Children

Date:
April 18, 2006
Source:
NIH/National Institute of Dental and Craniofacial Research
Summary:
Mercury-containing dental amalgam fillings had no adverse health effects in children after five and seven years, according to the first randomized safety trials on the subject.

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, report in this week's Journal of the American Medical Association the results of the first-ever randomized clinical trials to evaluate the safety of placing amalgam fillings, which contain mercury, in the teeth of children.

Both studies--one conducted in Europe, the other in the United States--independently reached the conclusion: Children whose cavities were filled with dental amalgam had no adverse health effects. The findings included no detectable loss of intelligence, memory, coordination, concentration, nerve conduction, or kidney function during the 5-7 years the children were followed. The researchers looked for measurable signs of damage to the brain and kidneys because previous studies with adults indicated these organs might be especially sensitive to mercury.

The authors noted that children in both studies who received amalgam, informally known as "silver fillings," had slightly elevated levels of mercury in their urine. But after several years of analysis, they determined the mercury levels remained low and did not correlate with any symptoms of mercury poisoning.

"What's particularly impressive is the strength of the evidence," said NIDCR director Dr. Lawrence Tabak. "The studies evaluated mercury exposure in two large, geographically distinct groups of children and reached similar conclusions about the safety of amalgam."

Dentists have used silver-colored amalgam to fill cavities for more than 150 years. The material is made from an alloy powder of silver, copper, zinc, and other metals held together like glue by mercury. The mercury comprises about half the total weight of a filling.

For decades, it was believed that a person's direct exposure to the mercury in amalgam was brief, occurring only while the dentist packed the filling into the tooth. But with the arrival of more sensitive laboratory tools in the late 1970s and into the 1980s, scientists showed that dental amalgam continuously releases a mercury vapor into the mouth, which is inhaled and absorbed by the body.

The discovery raised concerns about the possible toxicity of chronic low-level exposure to mercury from dental amalgam. The toxicity of mercury at higher levels, such as from industrial exposures, is well established. Possible symptoms of mercury poisoning include irritability, memory loss, tremors, poor physical coordination, insomnia, kidney failure and anorexia.

To help fill gaps in knowledge about the potential risks of dental amalgam, the NIDCR began supporting in 1996 the first two safety trials of amalgam in children. The decision to support the trials stemmed in part from the fact that millions of children receive amalgam fillings each year. But nearly all of the available safety data on mercury exposure involved adults, typically those who worked in environments where the element is present in relatively large doses, such as dental offices.

"It was clear that we needed to determine whether the potential risks of dental amalgam in any way outweigh its benefits, and we needed to make the determination first in children, who may be more sensitive to any adverse effects of mercury," said Tabak.

The two studies, whose results are reported this week in JAMA, are: the New England study, which was undertaken in the urban Boston, Mass. area and rural Farmington, Maine, and the Portuguese study, conducted in Lisbon, Portugal. Each study enrolled over 500 children who had existing untreated decay in permanent posterior, or back, teeth but no previously placed dental amalgam fillings. Each child was randomly assigned to receive either amalgam or composite resin (tooth colored) fillings while participating in the research studies.

All were evaluated for several years thereafter to determine if any health changes occurred, with emphases on IQ changes in the New England study and memory, concentration, coordination, and nerve conduction measures in the Portuguese study.

"The children received free comprehensive dental care while they participated in both studies," said Dr. Tim DeRouen, the principal investigator of the Portuguese study and a scientist at the University of Washington in Seattle. "These treatments represent the standard of care for kids with cavities throughout most of the world."

In the Portuguese study, which enrolled children ages eight through 10, DeRouen and colleagues found no differences over seven years between the 253 participants who received amalgam fillings and the 254 volunteers who were treated with composites. This conclusion was reached following annual standardized tests of memory, attention, physical coordination, and velocity of nerve conduction. Neither did the scientists detect a pattern of decline in the test scores of individual children who received amalgam fillings.

DeRouen noted that children who received amalgam fillings had slightly elevated levels of mercury in their urine, measuring on average 1.5 micrograms per liter of urine for the first two years and leveling off to 1.0 micrograms per liter or less thereafter. However, these numbers fall within the so-called "background" level (0-4 micrograms per liter) that is typical for an average person not exposed to industrial or other known sources of mercury. A microgram equals one millionth of a gram.

The scientists noted that children in both groups were in great need of dental care. Among those in the amalgam group, children had on average 10.1 tooth surfaces treated upon entry into the study. By year seven of the study, they had received on average a total of 18.7 surface restorations. Each tooth has either four or five defined surface areas, totaling 128 surfaces in our 32 permanent teeth.

In the New England study, which enrolled children ages six through 10, the scientists also found after five years no significant differences in the well being of the 267 participants who randomly received amalgam and their 267 counterparts who received composite fillings. "We took great pains to design our study in a way that our tests would be sensitive enough to detect as little as a three-point drop in IQ," said Dr. Sonja McKinlay, the principal investigator of the American study and a scientist at New England Research Institutes in Watertown, Mass. "What we found over the course of the study is the amalgam fillings had no adverse effects on the IQ of these children as well as on a range of other neuropsychological measures and kidney function."

The New England scientists also found that children with amalgam fillings had very slightly increased mercury in their urine. On average, these children had mercury levels of 1.0 micrograms per liter of urine compared to an average measure of 0.5 in those who received composite fillings. Both averages remained within the range of background exposure and were not related to IQ, other tests of brain function, or kidney function.

The New England study participants also had fairly extensive tooth decay, with 9.5 decayed tooth surfaces at the start of the study, of which 1.7 were in permanent teeth. By the end of the study, the children had on average 15 tooth surfaces restored. In the United States, children between the age of 6 and 10 have on average only 1.6 decayed surfaces among both their primary and permanent teeth.

"Given the rigorous nature of the study designs and that both clinical trials confirmed the other's results, I think these findings should be reassuring for parents, children, and dental professionals," said McKinlay.



Story Source:

The above story is based on materials provided by NIH/National Institute of Dental and Craniofacial Research. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute of Dental and Craniofacial Research. "Studies Evaluate Health Effects Of Dental Amalgam In Children." ScienceDaily. ScienceDaily, 18 April 2006. <www.sciencedaily.com/releases/2006/04/060418175827.htm>.
NIH/National Institute of Dental and Craniofacial Research. (2006, April 18). Studies Evaluate Health Effects Of Dental Amalgam In Children. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2006/04/060418175827.htm
NIH/National Institute of Dental and Craniofacial Research. "Studies Evaluate Health Effects Of Dental Amalgam In Children." ScienceDaily. www.sciencedaily.com/releases/2006/04/060418175827.htm (accessed September 30, 2014).

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