Featured Research

from universities, journals, and other organizations

Targeting Lung Cancer

Date:
May 17, 2006
Source:
Cold Spring Harbor Laboratory
Summary:
As reported in the June 1 issue of G&D, Drs. Katerina Politi, Harold Varmus and colleagues at the Memorial Sloan Kettering Cancer Center in New York have developed a novel animal model of lung adenocarcinoma that will be of great use in testing the efficacy of targeted therapies against human lung cancer.

As reported in the June 1 issue of G&D, Drs. Katerina Politi, Harold Varmus and colleagues at the Memorial Sloan Kettering Cancer Center in New York have developed a novel animal model of lung adenocarcinoma that will be of great use in testing the efficacy of targeted therapies against human lung cancer.

Related Articles


"We hope to use these models to understand how mutations in the EGFR gene initiate lung tumors, which are the most common cause of cancer mortality . In addition, these models will allow us to evaluate the effectiveness of new drugs and drug combinations and to study the molecular basis of resistance to existing tyrosine kinase inhibitors," explains Dr. Politi.

Lung cancer patients who harbor mutations in the human epidermal growth factor receptor (EGFR) gene generally have a better response to drugs that inhibit EGFR (like Iressa and Tarceva). Dr. Politi and colleagues have engineered a strain of mice with a mutated form of EGFR that can be turned on or off in lung cells at will. These inducible EGFR-mutant mice allow the researchers to evaluate the contribution of EGFR mutations to lung cancer formation, progression and response to chemotherapeutics.

The researchers found that mutations in EGFR drive lung tumorigenesis, and that either turning off the mutant EGFR gene or inhibiting it with drug can effectively force the tumors into regression. Thus, their model not only lends mechanistic insight into the genetic factors involved in lung cancer, but also serves as a paradigm to develop, test, and hopefully improve targeted cancer therapies.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Targeting Lung Cancer." ScienceDaily. ScienceDaily, 17 May 2006. <www.sciencedaily.com/releases/2006/05/060517180153.htm>.
Cold Spring Harbor Laboratory. (2006, May 17). Targeting Lung Cancer. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2006/05/060517180153.htm
Cold Spring Harbor Laboratory. "Targeting Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/05/060517180153.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins