Featured Research

from universities, journals, and other organizations

Oxygen Deprived Brains Repaired And Saved

Date:
August 26, 2006
Source:
Howard Florey Institute, University of Melbourne
Summary:
Scientists from Melbourne's Howard Florey Institute have found special proteins that protect the brain after it has been damaged by a lack of oxygen, which occurs in conditions such as stroke, perinatal asphyxia, near-drowning and traumatic brain injury.

Scientists from Melbourne's Howard Florey Institute have found special proteins that protect the brain after it has been damaged by a lack of oxygen, which occurs in conditions such as stroke, perinatal asphyxia, near-drowning and traumatic brain injury.

Dr Nicole Jones and her team discovered that during oxygen deprivation, or 'hypoxia', these proteins (HIF1 and PHD2) increase.

These proteins regulate processes like the production of red blood cells and new blood vessels, and the flow of glucose to the brain. Therefore they are involved in preventing further brain damage and repairing damage caused by the initial injury.

This discovery takes the Howard Florey Institute's scientists closer to developing preventative and regenerative treatments for brain damage caused by hypoxia.

Dr Jones said her discovery resulted from looking at how the body tries to protect itself and how the brain reacts when it experiences mild, non-damaging hypoxia.

"I found that mild, non-damaging hypoxia actually protected the brain against a subsequent injury by activating certain proteins," Dr Jones said.

"Mild hypoxia appears to pre-condition neural tissues against a mass 'suicide' of healthy neurons after a stroke or other brain trauma.

"In an experiment in rats, mild hypoxia followed by a major stroke resulted in less brain damage than if the rat experienced just a major stroke -- all because these protective proteins were increased by the first non-damaging exposure to hypoxia.

"I am now looking at developing both preventative and regenerative treatments that mimic these proteins' protective and repairing effects," she said.

Dr Jones is now testing drug candidates, and would like to develop new drugs that activate these protective proteins in the brain.

While further research is required, Dr Jones and her team are hopeful that their investigations will lead to effective treatments that will help people experiencing hypoxia, and also to improve recovery from hypoxic induced brain damage.

Dr Jones' research has been recently published in the Journal of Cerebral Blood Flow and Metabolism and Neuroscience Letters.

The Howard Florey Institute is Australia's leading brain research centre. Its scientists undertake clinical and applied research that can be developed into treatments to combat brain disorders, and new medical practices. Their discoveries will improve the lives of those directly, and indirectly, affected by brain and mind disorders in Australia, and around the world. The Florey's research areas cover a variety of brain and mind disorders including Parkinson's disease, stroke, motor neuron disease, addiction, epilepsy, multiple sclerosis, autism and dementia.


Story Source:

The above story is based on materials provided by Howard Florey Institute, University of Melbourne. Note: Materials may be edited for content and length.


Cite This Page:

Howard Florey Institute, University of Melbourne. "Oxygen Deprived Brains Repaired And Saved." ScienceDaily. ScienceDaily, 26 August 2006. <www.sciencedaily.com/releases/2006/08/060824224201.htm>.
Howard Florey Institute, University of Melbourne. (2006, August 26). Oxygen Deprived Brains Repaired And Saved. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2006/08/060824224201.htm
Howard Florey Institute, University of Melbourne. "Oxygen Deprived Brains Repaired And Saved." ScienceDaily. www.sciencedaily.com/releases/2006/08/060824224201.htm (accessed July 22, 2014).

Share This




More Mind & Brain News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com
Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Newsy (July 18, 2014) A new study suggests that mixing alcohol with energy drinks makes you want to keep the party going. Video provided by Newsy
Powered by NewsLook.com
Pot Cooking Class Teaches Responsible Eating

Pot Cooking Class Teaches Responsible Eating

AP (July 18, 2014) Following the nationwide trend of eased restrictions on marijuana use, pot edibles are growing in popularity. One Boston-area cooking class is teaching people how to eat pot responsibly. (July 18) Video provided by AP
Powered by NewsLook.com
Understanding D.C.'s New Pot Laws

Understanding D.C.'s New Pot Laws

Newsy (July 17, 2014) Washington D.C.'s new laws decriminalizing small amount of marijuana went into effect Thursday. Here's how they work. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins