Featured Research

from universities, journals, and other organizations

Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests

Date:
January 30, 2007
Source:
John Wiley & Sons, Inc.
Summary:
G. Whitesides and his team at Harvard University have developed a prototype for an inexpensive, highly practical rapid test that can be used to carry out several biological tests simultaneously on a single drop. As they describe in the journal Angewandte Chemie, their tests are based on tiny pieces of paper onto which defined, millimeter-sized channels are printed.

Testing biological fluids such as blood and urine is essential for both diagnostics and routine checks. In remote, non-industrialized regions or for emergency on-the-spot diagnosis, current methods of laboratory analysis are far too complicated. George M. Whitesides and his team at Harvard University in Cambridge, Massachusetts (USA) have now developed a prototype for a new class of inexpensive, highly practical rapid tests that can be used to carry out several biological tests simultaneously on a single drop. As they describe in the journal Angewandte Chemie, their tests are based on tiny pieces of paper onto which defined, millimeter-sized channels are printed.

To produce these, highly absorbent paper is treated with a photosensitive coating and covered with a mask that is the negative of the desired pattern. When the paper is irradiated with UV light through the mask, the molecules of the photosensitive coating change so that subsequent heating converts them to a continuous polymer layer. The untreated coating under the mask can be washed away, while the polymer layer on the irradiated spots is bound fast to the paper. This system allows the researchers to produce a tiny system of channels separated from each other by “channel walls” made of the water-repellent polymer.

As a prototype, Whitesides and his team selected a clover-leaf-shaped channel system: A main channel branches into three tiny chambers. Different color reagents are introduced into each of these chambers and are allowed to dry. The first chamber contains a reagent for a glucose test and the second a protein test; the third is a control. When a drop of liquid is introduced, the capillary action of the paper quickly sucks it up and transports it into all three chambers. A series of tests with artificial urine demonstrated that the intensity of the (simultaneously occurring) color reactions corresponds to the glucose and protein concentrations. The sensitivity of detection is comparable to conventional glucose and protein test strips.

Crucial to implementation in the field, the tests are not affected by contamination by dust, dirt, or plant materials, because these particles are not absorbed by the paper.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests." ScienceDaily. ScienceDaily, 30 January 2007. <www.sciencedaily.com/releases/2007/01/070130091946.htm>.
John Wiley & Sons, Inc.. (2007, January 30). Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/01/070130091946.htm
John Wiley & Sons, Inc.. "Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests." ScienceDaily. www.sciencedaily.com/releases/2007/01/070130091946.htm (accessed July 31, 2014).

Share This




More Matter & Energy News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Britain Testing Driverless Cars on Roadways

Britain Testing Driverless Cars on Roadways

AP (July 30, 2014) British officials said on Wednesday that driverless cars will be tested on roads in as many as three cities in a trial program set to begin in January. Officials said the tests will last up to three years. (July 30) Video provided by AP
Powered by NewsLook.com
Amid Drought, UCLA Sees Only Water

Amid Drought, UCLA Sees Only Water

AP (July 30, 2014) A ruptured 93-year-old water main left the UCLA campus awash in 8 million gallons of water in the middle of California's worst drought in decades. (July 30) Video provided by AP
Powered by NewsLook.com
Smartphone Powered Paper Plane Debuts at Airshow

Smartphone Powered Paper Plane Debuts at Airshow

AP (July 30, 2014) Smartphone powered paper airplane that was popular on crowdfunding website KickStarter makes its debut at Wisconsin airshow (July 30) Video provided by AP
Powered by NewsLook.com
U.K. To Allow Driverless Cars On Public Roads

U.K. To Allow Driverless Cars On Public Roads

Newsy (July 30, 2014) Driverless cars could soon become a staple on U.K. city streets, as they're set to be introduced to a few cities in 2015. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins