Featured Research

from universities, journals, and other organizations

Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests

Date:
January 30, 2007
Source:
John Wiley & Sons, Inc.
Summary:
G. Whitesides and his team at Harvard University have developed a prototype for an inexpensive, highly practical rapid test that can be used to carry out several biological tests simultaneously on a single drop. As they describe in the journal Angewandte Chemie, their tests are based on tiny pieces of paper onto which defined, millimeter-sized channels are printed.

Testing biological fluids such as blood and urine is essential for both diagnostics and routine checks. In remote, non-industrialized regions or for emergency on-the-spot diagnosis, current methods of laboratory analysis are far too complicated. George M. Whitesides and his team at Harvard University in Cambridge, Massachusetts (USA) have now developed a prototype for a new class of inexpensive, highly practical rapid tests that can be used to carry out several biological tests simultaneously on a single drop. As they describe in the journal Angewandte Chemie, their tests are based on tiny pieces of paper onto which defined, millimeter-sized channels are printed.

To produce these, highly absorbent paper is treated with a photosensitive coating and covered with a mask that is the negative of the desired pattern. When the paper is irradiated with UV light through the mask, the molecules of the photosensitive coating change so that subsequent heating converts them to a continuous polymer layer. The untreated coating under the mask can be washed away, while the polymer layer on the irradiated spots is bound fast to the paper. This system allows the researchers to produce a tiny system of channels separated from each other by “channel walls” made of the water-repellent polymer.

As a prototype, Whitesides and his team selected a clover-leaf-shaped channel system: A main channel branches into three tiny chambers. Different color reagents are introduced into each of these chambers and are allowed to dry. The first chamber contains a reagent for a glucose test and the second a protein test; the third is a control. When a drop of liquid is introduced, the capillary action of the paper quickly sucks it up and transports it into all three chambers. A series of tests with artificial urine demonstrated that the intensity of the (simultaneously occurring) color reactions corresponds to the glucose and protein concentrations. The sensitivity of detection is comparable to conventional glucose and protein test strips.

Crucial to implementation in the field, the tests are not affected by contamination by dust, dirt, or plant materials, because these particles are not absorbed by the paper.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests." ScienceDaily. ScienceDaily, 30 January 2007. <www.sciencedaily.com/releases/2007/01/070130091946.htm>.
John Wiley & Sons, Inc.. (2007, January 30). Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/01/070130091946.htm
John Wiley & Sons, Inc.. "Diagnosis By Patterned Paper: Photoprinted Paper Supports Simultaneous Microscale Diagnostic Tests." ScienceDaily. www.sciencedaily.com/releases/2007/01/070130091946.htm (accessed September 30, 2014).

Share This



More Matter & Energy News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Argentina's Tax Evaders Detected, Hunted Down by Drones

Argentina's Tax Evaders Detected, Hunted Down by Drones

AFP (Sep. 30, 2014) Argentina doesn't only have Lionel Messi the footballer, it has now also acquired "Mesi" the drone system which monitors undeclared mansions, swimming pools and soy fields to curb tax evasion in the country. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
CERN Celebrates 60 Years of Science

CERN Celebrates 60 Years of Science

Reuters - Business Video Online (Sep. 29, 2014) CERN, the European Organisation for Nuclear Research, celebrates 60 years of bringing nations together through science. As Joanna Partridge reports from inside the famous science centre it's also planning to turn the Large Hadron Collider particle accelerator back on after an upgrade. Video provided by Reuters
Powered by NewsLook.com
This 'Invisibility Cloak' Is Simpler Than Most

This 'Invisibility Cloak' Is Simpler Than Most

Newsy (Sep. 28, 2014) Researchers from the University of Rochester have created a type of invisibility cloak with simple focal lenses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins