Featured Research

from universities, journals, and other organizations

LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA

Date:
April 4, 2007
Source:
Virginia Tech
Summary:
Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses. Testing the activity of each of the therapeutic molecule designs has been a time-consuming process. But a student's invention now provides rapid screening to accelerate discovery of promising new drugs.

A Virginia Tech student has created an LED system that glows a beautiful shade of blue when special molecules successfully bind to DNA.
Credit: David Zigler

Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses. Testing the activity of each of the therapeutic molecule designs has been a time-consuming process. But a student's invention now provides rapid screening to accelerate discovery of promising new drugs.

Aaron J. (A.J.) Prussin II of Blacksburg, Va., a second year student at Virginia Tech who is majoring in biochemistry and biology, with a minor in chemistry, has created an LED system that glows a beautiful shade of blue when the special molecules successfully bind to DNA. "It allows us to do 100 tests per day, instead of one or two," said Karen Brewer, professor of chemistry at Virginia Tech.

The research will be presented at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.

Pussin and chemistry graduate student David Zigler of Sterling, Illinois, plan next to build an array that will use different colors to signal different DNA interactions. "That capability is important in terms of what color of light you want to use to activate the molecules to bind to or cleave the DNA," Brewer said.

The research poster, "Validation of an LED array for use in DNA photocleavage assays" (INOR 726), was selected for both the Bioinorganic: DNA and RNA poster session and for the special Sci-Mix session at the national meeting.

Authors are Prussin, Zigler, chemistry graduate students Jared Brown and Avijita Jain, Biology Professor Brenda S. J. Winkel, and Brewer.

The research was supported by the National Science Foundation.


Story Source:

The above story is based on materials provided by Virginia Tech. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Tech. "LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA." ScienceDaily. ScienceDaily, 4 April 2007. <www.sciencedaily.com/releases/2007/03/070327095204.htm>.
Virginia Tech. (2007, April 4). LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2007/03/070327095204.htm
Virginia Tech. "LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA." ScienceDaily. www.sciencedaily.com/releases/2007/03/070327095204.htm (accessed September 23, 2014).

Share This



More Matter & Energy News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Will Living Glue Be A Thing?

Will Living Glue Be A Thing?

Newsy (Sep. 23, 2014) Using proteins derived from mussels, engineers at MIT have made a supersticky underwater adhesive. They're now looking to make "living glue." Video provided by Newsy
Powered by NewsLook.com
Company Copies Keys From Photos

Company Copies Keys From Photos

Newsy (Sep. 22, 2014) A new company allows customers to make copies of keys by simply uploading a couple of photos. But could it also be great for thieves? Video provided by Newsy
Powered by NewsLook.com
The Hyped-Up Big Bang Discovery Has A Dust Problem

The Hyped-Up Big Bang Discovery Has A Dust Problem

Newsy (Sep. 22, 2014) An analysis of new satellite data casts serious doubt on a previous study about the Big Bang that was once hailed as revolutionary. Video provided by Newsy
Powered by NewsLook.com
Rockefeller Oil Heirs Switching To Clean Energy

Rockefeller Oil Heirs Switching To Clean Energy

Newsy (Sep. 22, 2014) The Rockefellers — heirs to an oil fortune that made the family name a symbol of American wealth — are switching from fossil fuels to clean energy. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins