Featured Research

from universities, journals, and other organizations

LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA

Date:
April 4, 2007
Source:
Virginia Tech
Summary:
Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses. Testing the activity of each of the therapeutic molecule designs has been a time-consuming process. But a student's invention now provides rapid screening to accelerate discovery of promising new drugs.

A Virginia Tech student has created an LED system that glows a beautiful shade of blue when special molecules successfully bind to DNA.
Credit: David Zigler

Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses. Testing the activity of each of the therapeutic molecule designs has been a time-consuming process. But a student's invention now provides rapid screening to accelerate discovery of promising new drugs.

Aaron J. (A.J.) Prussin II of Blacksburg, Va., a second year student at Virginia Tech who is majoring in biochemistry and biology, with a minor in chemistry, has created an LED system that glows a beautiful shade of blue when the special molecules successfully bind to DNA. "It allows us to do 100 tests per day, instead of one or two," said Karen Brewer, professor of chemistry at Virginia Tech.

The research will be presented at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.

Pussin and chemistry graduate student David Zigler of Sterling, Illinois, plan next to build an array that will use different colors to signal different DNA interactions. "That capability is important in terms of what color of light you want to use to activate the molecules to bind to or cleave the DNA," Brewer said.

The research poster, "Validation of an LED array for use in DNA photocleavage assays" (INOR 726), was selected for both the Bioinorganic: DNA and RNA poster session and for the special Sci-Mix session at the national meeting.

Authors are Prussin, Zigler, chemistry graduate students Jared Brown and Avijita Jain, Biology Professor Brenda S. J. Winkel, and Brewer.

The research was supported by the National Science Foundation.


Story Source:

The above story is based on materials provided by Virginia Tech. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Tech. "LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA." ScienceDaily. ScienceDaily, 4 April 2007. <www.sciencedaily.com/releases/2007/03/070327095204.htm>.
Virginia Tech. (2007, April 4). LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2007/03/070327095204.htm
Virginia Tech. "LED Array Signals Successful Binding Of Drug-delivery Molecules To DNA." ScienceDaily. www.sciencedaily.com/releases/2007/03/070327095204.htm (accessed July 22, 2014).

Share This




More Matter & Energy News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Government Approves East Coast Oil Exploration

Government Approves East Coast Oil Exploration

AP (July 18, 2014) The Obama administration approved the use of sonic cannons to discover deposits under the ocean floor by shooting sound waves 100 times louder than a jet engine through waters shared by endangered whales and turtles. (July 18) Video provided by AP
Powered by NewsLook.com
Sunken German U-Boat Clearly Visible For First Time

Sunken German U-Boat Clearly Visible For First Time

Newsy (July 18, 2014) The wreckage of the German submarine U-166 has become clearly visible for the first time since it was discovered in 2001. Video provided by Newsy
Powered by NewsLook.com
Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Reuters - US Online Video (July 17, 2014) President Barak Obama stopped by at a lunch counter in Delaware before making remarks about boosting the nation's infrastructure. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

TheStreet (July 16, 2014) Oil Futures are bouncing back after tumbling below $100 a barrel for the first time since May yesterday. Jeff Grossman is the president of BRG Brokerage and trades at the NYMEX. Grossman tells TheStreet the Middle East is always a concern for oil traders. Oil prices were pushed down in recent weeks on Libya increasing its production. Supply disruptions in Iraq fading also contributed to prices falling. News from China's economic front showing a growth for the second quarter also calmed fears on its slowdown. Jeff Grossman talks to TheStreet's Susannah Lee on this and more on the Energy Department's Energy Information Administration (EIA) report. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins