Featured Research

from universities, journals, and other organizations

Aspirin Discovery May Improve Cancer Treatments

Date:
April 6, 2007
Source:
Monash Institute Of Medical Research
Summary:
Scientists have uncovered the molecular pathways involved in the inhibition of protein synthesis in cells by aspirin, a discovery that may have implications for the treatment of cancer.

Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood.

Related Articles


In a paper published in the prestigious Journal of Biological Chemistry in April, Professor Bryan Williams, Director of the Monash Institute of Medical Research, led a collaborative study that investigated the effects of salicylates on the inhibition of protein synthesis.

"Our research showed that treating human cells with salicylates results in the phosphorylation of the translation initiation factor eIF2ƒ, thus inhibiting protein synthesis," Professor Williams said.

"Inhibiting or slowing down protein synthesis reduces the accumulation of incorrectly folded proteins in cells, which reduces cellular stress and allows protein synthesis to return to normal."

Under conditions of cellular stress, eIF2ƒ is phosphorylated by a group of proteins called stress-activated kinases. One of these is protein kinase R-like endoplasmic reticulum kinase (PERK).

The research showed that salicylates caused an early increase in the phosphorylation of eIF2ƒ in normal mouse cells, but not in cells deficient in PERK. Aspirin was shown to activate PERK. Moreover, although aspirin inhibited protein synthesis in normal cells, this did not occur significantly in cells deficient in PERK. Thus PERK plays an important role in the inhibition of protein synthesis by salicylates.

"Our research into the mechanisms by which salicylates inhibit protein synthesis could lead to the design of more effective aspirin-like drugs for the treatment of diseases such as cancer," Professor Williams said.


Story Source:

The above story is based on materials provided by Monash Institute Of Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Monash Institute Of Medical Research. "Aspirin Discovery May Improve Cancer Treatments." ScienceDaily. ScienceDaily, 6 April 2007. <www.sciencedaily.com/releases/2007/04/070405094133.htm>.
Monash Institute Of Medical Research. (2007, April 6). Aspirin Discovery May Improve Cancer Treatments. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2007/04/070405094133.htm
Monash Institute Of Medical Research. "Aspirin Discovery May Improve Cancer Treatments." ScienceDaily. www.sciencedaily.com/releases/2007/04/070405094133.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rare Goblin Shark Found in Australia

Rare Goblin Shark Found in Australia

AFP (Mar. 3, 2015) A goblin shark, a rare sea creature described as an &apos;alien of the deep&apos; is found off Australia and delivered to the Australian Museum in Sydney. Duration: 01:25 Video provided by AFP
Powered by NewsLook.com
500 Snakes Surprise Construction Workers In Canada

500 Snakes Surprise Construction Workers In Canada

Newsy (Mar. 2, 2015) Hundreds of snakes, disturbed by a construction project, were relocated to a wildlife rescue association in Canada. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
Zookeepers Copy Animal Poses In Hilarious Viral Photos

Zookeepers Copy Animal Poses In Hilarious Viral Photos

Buzz60 (Mar. 2, 2015) Zookeepers at the Symbio Wildlife Park in Helensburgh, Australia decided to take some of their favorite animal photos and recreate them by posing just like the animals. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins