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New Chemical Effective Against Anthrax

Date:
April 23, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Scientists have identified a chemical that could be used as a new drug against anthrax.
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Scientists have identified a chemical that could be used as a new drug against anthrax.

Anthrax is a deadly disease caused by spores that germinate into bacteria, which then release a deadly toxin. Spores that are inhaled by animals or people germinate in the lungs to form bacteria, which then spread throughout the body, releasing the toxin and triggering the disease. Since spore germination is needed to cause infection, preventing germination is a potentially efficient way to stop the infection.

Jurgen Brojatsch, Ernesto Abel-Santos, and colleagues identified seven chemicals that block the germination of cultured anthrax spores. They also showed that one of these compounds, 6-thioguanosine, blocked the spores' germination inside mammalian cells, thus blocking anthrax infection. The scientists are now planning to test 6-thioguanosine in mice infected with the anthrax bacterium. This compound is a known anticancer agent with well-studied pharmacological properties, which could help save time and money if it is used in clinical trials.

Article: "Identification of an in Vivo Inhibitor of Bacillus anthracis Spore Germination" by Monique Akoachere, Raynal C. Squires, Adel M. Nour, Ludmyl Angelov, Jurgen Brojatsch, and Ernesto Abel-Santos


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The above post is reprinted from materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


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American Society for Biochemistry and Molecular Biology. "New Chemical Effective Against Anthrax." ScienceDaily. ScienceDaily, 23 April 2007. <www.sciencedaily.com/releases/2007/04/070421211206.htm>.
American Society for Biochemistry and Molecular Biology. (2007, April 23). New Chemical Effective Against Anthrax. ScienceDaily. Retrieved August 31, 2015 from www.sciencedaily.com/releases/2007/04/070421211206.htm
American Society for Biochemistry and Molecular Biology. "New Chemical Effective Against Anthrax." ScienceDaily. www.sciencedaily.com/releases/2007/04/070421211206.htm (accessed August 31, 2015).

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