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New Treatment Slows Growth Of Colon And Liver Cancers In Mice

Date:
June 24, 2007
Source:
Basque Research
Summary:
Scientists have developed a new treatment which slows the growth of colon and liver cancers. Experimentation with the new drug in mice has shown that it slows tumor growth with respect to those animals subjected to other procedures.

Leire Garcํa Navarro
Credit: Universidad de Navarra

Leire Garcํa Navarro, a researcher at the School of Pharmacy of the University of Navarra, has developed a new treatment which slows the growth of colon and liver cancers.

This discovery is the principal result of her doctoral dissertation, entitled “Lipo-Polymeric Vectors for the Transfer of DNA in Cancer Cells of the Colon”, which was subsidized by the Basque Government.

In order to carry out the study, this scientist of the Department of Pharmacy and Pharmaceutical Technology used genetic therapy with non-viral vectors for transferring genetic material to the cancerous cells. With this technique, one can assure the therapeutic function of the drug in a wide variety of tissues. In addition, the treatment can be applied repeatedly, since it does not generate immunity, as occurs with viral vectors.

With the objective of improving the effectiveness of this methodology, the specialist worked on designing non-viral systems which act directly upon the liver and the colon. In this manner, she prepared, optimized and evaluated, in vitro and in vivo, a new pharmaceutical format called ‘lipopolyplex.’ This compound aids the genetic material in penetrating into the damaged cells, and allows drug release in tumorous organs.

500,000 deaths per year

Experimentation with the new drug in mice has shown that it slows tumor growth with respect to those animals subjected to other procedures. This diminishing of the cancerogenous area is possible, according to the scientist, thanks to the stimulation of the immune system, since the introduction of the correct gene in the diseased body can cause it to repair itself and destroy the tumor.

In addition, the researcher of the University of Navarra noted that colon cancer alone causes more than 500,000 deaths per year in the West, and currently the only effective treatment is surgery. Despite this treatment, noted the researcher, between 40 and 60% of colon cancer patients die, and for this reason it is important that scientists seek out treatment options based on genetic therapy.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Cite This Page:

Basque Research. "New Treatment Slows Growth Of Colon And Liver Cancers In Mice." ScienceDaily. ScienceDaily, 24 June 2007. <www.sciencedaily.com/releases/2007/06/070621102600.htm>.
Basque Research. (2007, June 24). New Treatment Slows Growth Of Colon And Liver Cancers In Mice. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2007/06/070621102600.htm
Basque Research. "New Treatment Slows Growth Of Colon And Liver Cancers In Mice." ScienceDaily. www.sciencedaily.com/releases/2007/06/070621102600.htm (accessed August 20, 2014).

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